Targeting disease-specific autoreactive T cells with Kv1.3 blockers: A new therapy for autoimmune diseases

被引:0
|
作者
Wulff, H
Mullen, K
Beeton, C
Wang, P
Counts, D
Calabresi, PA
Chandy, KG
机构
[1] Univ Calif Davis, Davis, CA 95616 USA
[2] Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA
[3] Univ Calif Irvine, Irvine, CA USA
关键词
D O I
暂无
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
引用
收藏
页码:21A / 21A
页数:1
相关论文
共 50 条
  • [31] Durable Pharmacological Responses from the Peptide ShK-186, a Specific Kv1.3 Channel Inhibitor That Suppresses T Cell Mediators of Autoimmune Disease
    Tarcha, Eric J.
    Chi, Victor
    Munoz-Elias, Ernesto J.
    Bailey, David
    Londono, Luz M.
    Upadhyay, Sanjeev K.
    Norton, Kayla
    Banks, Amy
    Tjong, Indra
    Hai Nguyen
    Hu, Xueyou
    Ruppert, Greg W.
    Boley, Scott E.
    Slauter, Richard
    Sams, James
    Knapp, Brian
    Kentala, Dustin
    Hansen, Zachary
    Pennington, Michael W.
    Beeton, Christine
    Chandy, K. George
    Iadonato, Shawn P.
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2012, 342 (03): : 642 - 653
  • [32] MEDI 577-Design of PAP-1, a selective small molecule Kv1.3 blocker for the suppression of effector memory T cells in autoimmune diseases
    Sankaranarayanan, Ananthakrishnan
    Azam, Philippe
    Homerick, Daniel
    Wulff, Heike
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 232
  • [33] Durable pharmacological responses from the peptide drug ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease
    Munoz, Ernesto
    Tarcha, Eric
    Londono, Luz
    Norton, Kayla
    Banks, Amy
    Chi, Victor
    Beeton, Christine
    Chandy, K.
    Iadonato, Shawn
    JOURNAL OF IMMUNOLOGY, 2012, 188
  • [34] Evidence for pathogenicity of autoreactive T cells in autoimmune bullous diseases shown by animal disease models
    Ujiie, Hideyuki
    Shimizu, Hiroshi
    EXPERIMENTAL DERMATOLOGY, 2012, 21 (12) : 901 - 905
  • [35] Lovastatin blocks Kv1.3 channel in human T cells: a new mechanism to explain its immunomodulatory properties
    Ning Zhao
    Qian Dong
    Cheng Qian
    Sen Li
    Qiong-Feng Wu
    Dan Ding
    Jing Li
    Bin-Bin Wang
    Ke-fang Guo
    Jiang-jiao Xie
    Xiang Cheng
    Yu-Hua Liao
    Yi-Mei Du
    Scientific Reports, 5
  • [36] Lovastatin blocks Kv1.3 channel in human T cells: a new mechanism to explain its immunomodulatory properties
    Zhao, Ning
    Dong, Qian
    Qian, Cheng
    Li, Sen
    Wu, Qiong-Feng
    Ding, Dan
    Li, Jing
    Wang, Bin-Bin
    Guo, Ke-fang
    Xie, Jiang-jiao
    Cheng, Xiang
    Liao, Yu-Hua
    Du, Yi-Mei
    SCIENTIFIC REPORTS, 2015, 5
  • [37] A Kv1.3 channel-specific blocker alleviates neurological impairment through inhibiting T-cell activation in experimental autoimmune encephalomyelitis
    Yuan, Xiao-Lu
    Zhao, Yi-Peng
    Huang, Jie
    Liu, Jun-Chen
    Mao, Wen-Qian
    Yin, Jun
    Peng, Bi-Wen
    Liu, Wan-Hong
    Han, Song
    He, Xiao-Hua
    CNS NEUROSCIENCE & THERAPEUTICS, 2018, 24 (10) : 967 - 977
  • [38] Pathophysiology of childhood polycystic kidney diseases: new insights into disease-specific therapy
    William E. Sweeney
    Ellis D. Avner
    Pediatric Research, 2014, 75 : 148 - 157
  • [39] Pathophysiology of childhood polycystic kidney diseases: new insights into disease-specific therapy
    Sweeney, William E., Jr.
    Avner, Ellis D.
    PEDIATRIC RESEARCH, 2014, 75 (01) : 148 - 157
  • [40] The voltage-gated Kv1.3 K+ channel in effector memory T cells: A new target for MS?
    Wulff, H
    Calabresi, PA
    Allie, R
    Yun, S
    Pennington, M
    Beeton, C
    Chandy, KG
    MULTIPLE SCLEROSIS, 2004, 10 (01):