Place of Artemisinin derivatives as anti-malarial drugs in paediatric hospitalization in Abidjan

The objective of this study is to analyze anti-malaria treatment and to appreciate the place of artemisinin and its derivatives in order to research rationality of prescriptions in paediatric hospitalization in Abidjan (C (o) over cap te d'lvoire). The investigation is based on a descriptive analysis related to 415 medical files constituting 646 prescriptions in four hospital centers. We considered therapeutic recommendations of PNLP (national program against malaria) to analyse these prescriptions. The correspondence factorial analysis has been used to appreciate different correlations between anti-malaria drugs use and type of malaria, patients' age, hospital... Artemisinin derivatives constitute the third of anti-malaria drugs prescribed to children. They are represented by artemether (most used), artesunate and artemether-lumefantrine combination. The treatment in emergency remains dominated by quinine. Amodiaquine and artesunate are the principal relay treatment with the detriment of chloroquine. Quinine remains the treatment of choice in paediatric hospitalization in complicated or uncomplicated malaria. The respect of national recommendations is not systematic. Some factors interfere in their no respect: physicians experience, existence of other hospital therapeutic protocols, pharmacoeconomics considerations, therapeutic antecedents, hospital availability of malaria drugs...