A toddler diagnosed with severe postinfectious bronchiolitis obliterans and COVID-19 infection

被引:1
|
作者
Koletsi, Patra [1 ]
Antoniadi, Marita [1 ]
Mermiri, Despina [1 ]
Koltsida, Georgia [2 ]
Koukou, Dimitra [2 ]
Noni, Maria [2 ]
Spoulou, Vasiliki [2 ]
Michos, Athanasios [2 ]
机构
[1] Penteli Childrens Hosp, Athens, Greece
[2] Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, Athens, Greece
关键词
antiviral agents; bronchiolitis obliterans; corticosteroids; COVID-19; treatment;
D O I
10.1002/ppul.25436
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
During the COVID-19 pandemic, management of SARS-CoV-2 infection in children with underlying chronic lung disease has been challenging. There are limited studies in children with respiratory comorbidities, apart from asthma, presumably due to low morbidity of SARS-CoV-2 infection in the general pediatric population along with the low incidence of certain pulmonary conditions. Compassionate use of remdesivir has been shown to reduce time to clinical improvement in adults and has been retrospectively studied in small pediatric cohorts with promising results. Whether children with underlying respiratory conditions may benefit from antiviral treatment in the context of different pathophysiologic backgrounds and unknown drug safety and efficacy needs to be further evaluated. We present a case of COVID-19 infection in a 3-year old toddler with severe postinfectious bronchiolitis obliterans, who received compassionate treatment with 5-day-course of remdesivir, and recovered with favourable outcome.
引用
收藏
页码:2381 / 2384
页数:4
相关论文
共 50 条
  • [41] A Fatal Case of Severe Breakthrough COVID-19 Infection
    Patel, K.
    Srinivasan, A.
    Wilson, B.
    Alam, J. M.
    Viroliya, K.
    Patel, S.
    Raghavan, R.
    Khulood, R.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2022, 205
  • [42] Management of Severe and Critical COVID-19 Infection with Immunotherapies
    Athale, Janhavi
    Gallagher, Jolie
    Busch, Lindsay M.
    INFECTIOUS DISEASE CLINICS OF NORTH AMERICA, 2022, 36 (04) : 761 - 775
  • [43] Severe hypocalcemia in a thyroidectomized woman with Covid-19 infection
    Bossoni, Simonetta
    Chiesa, Laura
    Giustina, Andrea
    ENDOCRINE, 2020, 68 (02) : 253 - 254
  • [44] Dexamethasone in severe COVID-19 infection: A case series
    Hassan, Mohamed Eliwa
    Hasan, Hasan M. S. N.
    Sridharan, Kannan
    Elkady, Adel
    ElSeirafi, Mohamed M. A.
    RESPIRATORY MEDICINE CASE REPORTS, 2020, 31
  • [45] Free DNA, a reason for severe COVID-19 infection?
    Liu, Bin
    MEDICAL HYPOTHESES, 2020, 142
  • [46] Leukemoid Reaction in a Patient With Severe COVID-19 Infection
    Tarekegn, Kidist
    Ramos, Ana Colon
    Gross, Harry G. Sequeira
    Yu, Ming
    Fulger, Ilmana
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2021, 13 (02)
  • [47] Potential neurological effects of severe COVID-19 infection
    Nuzzo, Domenico
    Picone, Pasquale
    NEUROSCIENCE RESEARCH, 2020, 158 : 1 - 5
  • [48] COVID-19–Associated Immune Thrombocytopenia in a Toddler
    Jayakrishnan Vadakkekara
    Rini Mathew
    Sanjeev Khera
    Indian Journal of Pediatrics, 2022, 89 : 623 - 623
  • [49] Histopathological and Clinical Analysis of 19 Placentas in Patients Diagnosed with COVID-19 Infection
    Ponce-Zepeda, Joaquin
    Wang, Beverly
    Tifrea, Delia
    Sheplay, Kirk
    Edwards, Robert
    MODERN PATHOLOGY, 2022, 35 (SUPPL 2) : 815 - 816
  • [50] Histopathological and Clinical Analysis of 19 Placentas in Patients Diagnosed with COVID-19 Infection
    Ponce-Zepeda, Joaquin
    Wang, Beverly
    Tifrea, Delia
    Sheplay, Kirk
    Edwards, Robert
    LABORATORY INVESTIGATION, 2022, 102 (SUPPL 1) : 815 - 816