Synthesis and in vitro microbiological evaluation of an array of biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides

被引：48

作者：

Kanagarajan, V. ^{[1
]}

Thanusu, J. ^{[1
]}

Gopalakrishnan, M. ^{[1
]}

机构：

[1] Annamalai Univ, Dept Chem, Synthet Organ Chem Lab, Annamalainagar 608002, Tamil Nadu, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 04期

关键词：

2-Amino-4,6-diarylpyrimidines; Morpholine; Acetamide; Chloroacetyl chloride; Antibacterial activity; Antifungal activity; ONE-POT SYNTHESIS; BIOLOGICAL EVALUATION; DESIGN; DERIVATIVES; INHIBITORS;

D O I：

10.1016/j.ejmech.2009.12.068

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides 34-42 have been synthesized and evaluated for their in vitro antibacterial and antifungal activities. The minimum inhibitory concentration tested for the same compounds against the same set of bacterial and fungal strains shows that the compounds 36 and 38 against beta-Heamolytic streptococcus and Klebsiella pneumonia, 40 against Escherichia coli and Pseudomonas, have excellent antibacterial activity. Compounds 36, 38 and 42 show inhibition against Aspergillus flavus, compound 41 against Microsporum gypsuem, 42 against Mucor, and compounds 39 and 40 against Rhizopus. (c) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：1583 / 1589

页数：7

共 50 条

[21] N-(4,6-DIMETHYLPYRIDINE-2-YL)(1-METHYLINDOL-2-YL)CARBOXAMIDE
RODIER, PN
CENSE, JM
ROBERT, JM
LEBAUT, G
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1992, 48 : 1148 - 1150
[22] Chiral N-(Octahydro-2H-chromen-4-yl)-2-(dialkylamino)acetamides: Synthesis and Analgesic Activity
Li-Zhulanov N.S.
Nikolaichuk K.M.
Gatilov Y.V.
Volcho K.P.
Khvostov M.V.
Tolstikova T.G.
Salakhutdinov N.F.
Doklady Chemistry, 2023, 512 (1) : 242 - 248
[23] SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 2-(2-(BENZO [D] OXAZOL-2-YL) PHENYLAMINO)-N-(SUBSTITUTED PHENYL) ACETAMIDES
Priyanka
Sharma, N. K.
Jha, K. K.
Kumar, M. Vijaya
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2014, 5 (08): : 3260 - 3266
[24] Synthesis of novel N-substituted benzyl N-(1,3-benzothiazol-2-yl) acetamides and their in vitro antibacterial activities
Sakarya, Handan Can
Gorgun, Kamuran
Iscen, Cansu Filik
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 2024, 89 (09) : S249 - +
[25] N-2-(4,6-DIMETHYLPYRID-2-YL)-N-1-METHYLPYRAZINE-2-CARBOXAMIDINE
RODIER, N
RIDEAU, O
ROBERT, JM
LEBAUT, G
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1994, 50 : 1760 - 1762
[26] Synthesis and Evaluation of N-(3-Trifluoroacetyl-indol-7-yl) Acetamides for Potential In Vitro Antiplasmodial Properties
Mphahlele, Malose J.
Mmonwa, Mmakwena M.
Choong, Yee Siew
MOLECULES, 2017, 22 (07):
[27] Insight into the inhibitory potential of metal complexes supported by (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine: synthesis, structural properties, biological evaluation and docking studies
Nayab, Saira
Jan, Kalsoom
Kim, Seung-Hyeon
Kim, Sa-Hyun
Shams, Dilawar Farhan
Son, Younghu
Yoon, Minyoung
Lee, Hyosun
DALTON TRANSACTIONS, 2024, 53 (27) : 11295 - 11309
[28] Synthesis and Evaluation of N-Phenyl-(2-aminothiazol-4-yl)acetamides with Phenoxypropanolamine Moiety as Selective β3-Adrenergic Receptor Agonists
Maruyama, Tatsuya
Onda, Kenichi
Suzuki, Takayuki
Hayakawa, Masahiko
Takahashi, Takumi
Matsui, Tetsuo
Takasu, Toshiyuki
Nagase, Itsuro
Ohta, Mitsuaki
CHEMICAL & PHARMACEUTICAL BULLETIN, 2012, 60 (05) : 647 - 658
[29] Synthesis of 2-(4-substitutedbenzylpiperazin-1-yl)-N-(2-oxo-2,3-dihydrobenzooxazol-6-yl)acetamides as Inotropic Agents
Zhang, Tianyi
Sun, Liangpeng
Liu, Xuekun
Cui, Xun
Piao, Huri
MEDICINAL CHEMISTRY, 2012, 8 (06) : 1093 - 1098
[30] N-(2,6-Difluorobenzoyl)-N′-(4,6-dimethoxypyrimidin-2-yl)urea
Wang, Qing-Dong
Xue, Si-Jia
Yan, Lin
Ke, Shao-Yong
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2006, 62 : O2824 - O2825

← 1 2 3 4 5 →