Role of Autophagy in Endothelial Damage and Blood-Brain Barrier Disruption in Ischemic Stroke

被引：72

作者：

Kim, Kyeong-A ^{[1
]}

Shin, Donggeun ^{[1
]}

Kim, Jeong-Hyeon ^{[1
]}

Shin, Young-Jun ^{[1
]}

Rajanikant, G. K. ^{[2
]}

Majid, Arshad ^{[3
]}

Baek, Seung-Hoon ^{[4
,5
]}

Bae, Ok-Nam ^{[1
]}

机构：

[1] Hanyang Univ, Inst Pharmaceut Sci & Technol, Coll Pharm, Ansan, South Korea

[2] Natl Inst Technol Calicut, Sch Biotechnol, Kozhikode, Kerala, India

[3] Univ Sheffield, Sheffield Inst Translat Neurosci, Sheffield, S Yorkshire, England

[4] Ajou Univ, Coll Pharm, Suwon, South Korea

[5] Ajou Univ, Res Inst Pharmaceut Sci & Technol, Suwon, South Korea

来源：

STROKE | 2018年 / 49卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

autophagy; blood-brain barrier; disease progression; endothelial cells; endothelial progenitor cells; FOCAL CEREBRAL-ISCHEMIA; PROGENITOR CELLS; OXIDATIVE STRESS; RAT MODEL; SELECTIVE AUTOPHAGY; PROTECTIVE ROLE; INJURY; NEUROPROTECTION; DYSFUNCTION; DEATH;

D O I：

10.1161/STROKEAHA.117.017287

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The global burden of neurological diseases including stroke has significantly increased, 1 and an urgent need exists to develop new treatment strategies. Impairment of autophagic regulation has been observed in diseases including neurodegenerative diseases and ischemic stroke, suggesting that modulation of autophagy could be a potential therapeutic target. 2 Endothelial cells (ECs) maintain homeostasis by regulating the vascular tone and permeability and endothelial dysfunction is associated with diverse cardiovascular diseases (CVDs). The integrity of the blood-brain barrier (BBB), which shows selective permeability for substances into the brain, is significantly impaired under ischemic stroke. This review focuses on autophagy in endothelial dysfunction in the context of ischemic stroke and potential targets for therapeutic manipulation.

引用

页码：1571 / 1579

页数：9

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