Endothelial dysfunction is associated with impaired lung function in two independent community cohorts

被引:4
|
作者
Rydell, Andreas [1 ,2 ]
Janson, Christer [3 ]
Lisspers, Karin [4 ]
Stallberg, Bjorn [4 ]
Nowak, Christoph [1 ]
Carlsson, Axel C. [1 ,3 ]
Feldreich, Tobias [5 ]
Iggman, David [2 ,6 ]
Lind, Lars [7 ]
Arnlov, Johan [1 ,2 ,5 ]
机构
[1] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, Huddinge, Sweden
[2] Norslund Svardsjo Primary Hlth Care Ctr, Dalarna Cty Council, Falun, Sweden
[3] Uppsala Univ, Dept Med Sci Resp Allergy & Sleep Res, Uppsala, Sweden
[4] Uppsala Univ, Dept Publ Hlth & Caring Sci, Family Med & Prevent Med, Uppsala, Sweden
[5] Dalarna Univ, Sch Hlth & Social Sci, Falun, Sweden
[6] Uppsala Univ, Dept Publ Hlth & Caring Sci, Unit Clin Nutr & Metab, Uppsala, Sweden
[7] Uppsala Univ, Dept Med Sci, Cardiovasc Epidemiol, Uppsala, Sweden
基金
瑞典研究理事会;
关键词
Lung function; Endothelial function; Endothelial dependent vasodilation; Forced expiratory volume; OBSTRUCTIVE PULMONARY-DISEASE; UPPSALA SENIORS PIVUS; DEPENDENT VASODILATION; CARDIOVASCULAR-DISEASE; VASCULAR DYSFUNCTION; RISK; SMOKERS; COPD; ATHEROSCLEROSIS; DETERMINANTS;
D O I
10.1016/j.rmed.2018.09.009
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Prior studies investigating the association between endothelial dysfunction and impaired lung function have been small and inconsistent. The primary aim was to investigate the association between endothelial function and lung function in two community-based cohorts. Methods: We used a discovery/replication approach to study the association between endothelial function and lung function in the Prospective investigation of Obesity, Energy and Metabolism (POEM, discovery cohort, n = 490, mean age 50.3 +/- 0.2 years) and the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS, replication cohort, n = 892, mean age 70.2 +/- 0.15 years). Spirometry and three different measures of endothelial function were performed including both the invasive forearm technique (endothelium-dependent and endothelium-independent vasodilation [EDV and EIDV, respectively] and noninvasive flow mediated dilation [FMD]). Results: An age and sex adjusted association between lower EDV and lower FEV1 was found in POEM and replicated in PIVUS. After merging the two cohorts, 1 standard deviation decrease in EDV was associated with 1.57% lower FEV1 after additional adjustment for smoking status, body mass index, exercise level, and C-reactive protein (95% confidence intervals 0.63-2.51, p = 0.001). The association was slightly lower albeit still statistically significant after excluding participants without cardiovascular disease and chronic respiratory disease and appeared stronger among previous/current smokers vs. non-smokers and in men vs. women (p for interaction = 0.2 and 0.02 respectively). Conclusions: Our findings suggest that even individuals with sub-clinical impairments of lung function in the community have concomitant endothelial dysfunction.
引用
收藏
页码:123 / 128
页数:6
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