Understanding the effect of magnesium degradation on drug release and anti-proliferation on smooth muscle cells for magnesium-based drug eluting stents

被引：33
|
作者：
Shi, Yongjuan [1 ,2 ]
Pei, Jia [1 ,2 ]
Zhang, Lei [1 ,2 ]
Lee, Byung Kook [3 ]
Yun, Yeonhee [3 ]
Zhang, Jian [1 ,2 ]
Li, Zhonghua [4 ]
Gu, Song [5 ]
Park, Kinam [3 ]
Yuan, Guangyin [1 ,2 ]
机构：
[1] Shanghai Jiao Tong Univ, Natl Engn Res Ctr Light Alloy Net Forming, Shanghai 200240, Peoples R China
[2] Shanghai Jiao Tong Univ, State Key Lab Met Matrix Composite, Shanghai 200240, Peoples R China
[3] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA
[4] Microport Endovasc Shanghai Co Ltd, Shanghai 201318, Peoples R China
[5] Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Shanghai 200127, Peoples R China
来源：
CORROSION SCIENCE | 2017年 / 123卷
关键词：
Magnesium; Organic coatings; Polymer; Erosion; Interfaces; Kinetic parameters; ABSORBABLE METAL SCAFFOLD; IN-VITRO DEGRADATION; ZN-ZR ALLOY; RAPAMYCIN; SIROLIMUS; BIODEGRADATION; MULTICENTER; MECHANISMS; DELIVERY; SAFETY;
D O I：
10.1016/j.corsci.2017.04.016
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
To understand the possible influence of substrate degradation on the drug-loading system of magnesium alloy-based drug-eluting stents, a rapamycin drug-loading poly(lactic-co-glycolic acid) coating was prepared on Mg-d-Zn-Zr stents for a systematic investigation in a phosphate buffer system. Mg degradation accelerated the drug release kinetics prominently, which was mainly attributed to H-2 evolution in the diffusion-controlled phase while thereafter to PLGA erosion. Although physiochemical stability of the released rapamycin was partially deteriorated by magnesium degradation, the drug-loading system on magnesium substrates exhibited a more potent long-term inhibition on smooth muscle cell proliferation in vitro as compared to drug-loaded stainless steel.
引用
收藏
页码：297 / 309
页数：13
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