RUNX transcription factors as key targets of TGF-β superfamily signaling

被引：314
|
作者：
Ito, Y
Miyazono, K
机构：
[1] Natl Univ Singapore, Inst Mol & Cell Biol, Singapore 117609, Singapore
[2] Natl Univ Singapore, Oncol Res Inst, Singapore 117609, Singapore
[3] Univ Tokyo, Grad Sch Med, Dept Mol Pathol, Bunkyo Ku, Tokyo 1130033, Japan
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2003年 / 13卷 / 01期
关键词：
D O I：
10.1016/S0959-437X(03)00007-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The Runt domain transcription factors, RUNX1, RUNX2 and RUNX3, are integral components of signaling cascades mediated by both TGF-beta and bone morphogenetic proteins (BMPs) in several important biological systems. RUNX2 functions synergistically with Smad1 and Smad5 to regulate bone-specific genes when BMP induces osteogenesis. RUNX3, which has been mapped to locus 1p36, is a major tumor suppressor of gastric cancer and appears to be an important component of the TGF-beta-induced tumor suppressor pathway. A possible relationship between the TGF-beta-induced tumor-suppressor pathway and a postulated tumor suppressor gene on 1p36 must be examined.
引用
收藏
页码：43 / 47
页数：5
相关论文
共 50 条
  • [41] Tgf-β superfamily and limb regeneration: Tgf-β to start and Bmp to end
    Sader, Fadi
    Roy, Stephane
    DEVELOPMENTAL DYNAMICS, 2022, 251 (06) : 973 - 987
  • [42] Bub1 is a key regulator of TGF-β signaling
    Nyati, Shyam
    Schinske-Sebolt, Katrina
    Pitchiaya, Sethuramasundaram
    Chekhovskiy, Katerina
    Chator, Areeb
    Chaudhry, Nauman
    Dosch, Joseph
    Van Dort, Marcian E.
    Varambally, Sooryanarayana
    Kumar-Sinha, Chandan
    Nyati, Mukesh K.
    Ray, Dipankar
    Walter, Nils G.
    Yu, Hongtao
    Ross, Brian D.
    Rehemtulla, Alnawaz
    CANCER RESEARCH, 2014, 74 (19)
  • [43] EHF promotes colorectal carcinoma progression by activating TGF-β1 transcription and canonical TGF-β signaling
    Wang, Lan
    Ai, Meiling
    Nie, Miaoting
    Zhao, Li
    Deng, Guangxu
    Hu, Shasha
    Han, Yue
    Zeng, Weiting
    Wang, Yiqing
    Yang, Minhui
    Wang, Shuang
    CANCER SCIENCE, 2020, 111 (07) : 2310 - 2324
  • [44] Inhibition of TGF-β-RUNX3 signaling by activated Shh is correlated with the development of TGF-β resistance in gastric cancer cells
    Park, Seong Nye
    Kim, Jung Lim
    Kim, Bo Ram
    Na, Yoo Jin
    Oh, Sang Cheul
    CANCER RESEARCH, 2015, 75
  • [45] Plum, an Immunoglobulin Superfamily Protein, Regulates Axon Pruning by Facilitating TGF-β Signaling
    Yu, Xiaomeng M.
    Gutman, Itai
    Mosca, Timothy J.
    Iram, Tal
    Oezkan, Engin
    Garcia, K. Christopher
    Luo, Liqun
    Schuldiner, Oren
    NEURON, 2013, 78 (03) : 456 - 468
  • [46] TGF-β receptors: In and beyond TGF-β signaling
    Ark, Alexandra Vander
    Cao, Jingchen
    Li, Xiaohong
    CELLULAR SIGNALLING, 2018, 52 : 112 - 120
  • [47] Structural studies of the TGF-βs and their receptors - insights into evolution of the TGF-β superfamily
    Hinck, Andrew P.
    FEBS LETTERS, 2012, 586 (14) : 1860 - 1870
  • [48] The transcription factor RUNX1 affects the maturation of porcine oocytes via the BMP15/TGF-? signaling pathway
    Li, Wentao
    Liu, Ziyi
    Wang, Peng
    Di, Ran
    Wang, Xiangyu
    Liu, Yufang
    Chu, Mingxing
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 238
  • [49] The TGF-β superfamily in dendritic cell biology
    Seeger, Pascal
    Musso, Tiziana
    Sozzani, Silvano
    CYTOKINE & GROWTH FACTOR REVIEWS, 2015, 26 (06) : 647 - 657
  • [50] TGF-β Signaling
    Tzavlaki, Kalliopi
    Moustakas, Aristidis
    BIOMOLECULES, 2020, 10 (03)
12345