Molecular characterization of lysyl oxidase-mediated extracellular matrix remodeling during mouse decidualization

被引：20
|
作者：
Li, Shu-Yun [1 ]
Yan, Jia-qi [1 ]
Song, Zhuo [1 ]
Liu, Yue-Fang [1 ]
Song, Min-Jie [1 ]
Qin, Jia-Wen [1 ]
Yang, Zeng-Ming [1 ]
Liang, Xiao-Huan [1 ]
机构：
[1] South China Agr Univ, Coll Vet Med, 483 Wushan Rd, Guangzhou, Guangdong, Peoples R China
来源：
FEBS LETTERS | 2017年 / 591卷 / 10期
基金：
中国国家自然科学基金;
关键词：
decidualization; Lox; uterus; EMBRYO IMPLANTATION; ESTROGEN; PROTEIN; ENDOMETRIUM; EXPRESSION; CANCER; METASTASIS; PATHWAY; BIOLOGY; UTERUS;
D O I：
10.1002/1873-3468.12645
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The establishment of decidualization is a prerequisite of successful pregnancy. Lysyl oxidase (Lox) is a copper-containing amine oxidase which catalyzes cross-linking of collagen and elastin in the ECM. Lox is expressed in the sub-luminal stroma surrounding the implanting blastocyst on day 5 of pregnancy. From days 6 to 8, the signals for Lox mRNA and protein are strongly detected in the decidual cells. The expression of Lox is under the control of estrogen via the GSK-3 beta/beta-catenin/c-myc pathway. Dtprp is decreased by the inhibition of Lox activity. Furthermore, the inhibition of Lox activity decreases stromal cell migration and embryo adhesion. Our findings highlight the crucial role of Lox in endometrial stromal cells and deepen our understanding of decidualization.
引用
收藏
页码：1394 / 1407
页数：14
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