The role of macrophages in anti-tumor immune responses: pathological significance and potential as therapeutic targets

被引：14
|
作者：
Tsukamoto, Hirotake [1 ,2 ]
Komohara, Yoshihiro [3 ]
Oshiumi, Hiroyuki [1 ]
机构：
[1] Kumamoto Univ, Grad Sch Med Sci, Dept Immunol, Kumamoto, Japan
[2] Kyoto Univ, Grad Sch Med, Ctr Canc Immunotherapy & Immunobiol, Div Clin Immunol & Canc Immunotherapy, Kyoto, Japan
[3] Kumamoto Univ, Grad Sch Med Sci, Dept Pathol, Chuo Ku, Honjo 1-1-1, Kumamoto 8608556, Japan
来源：
HUMAN CELL | 2021年 / 34卷 / 04期
关键词：
Cancer; Macrophage; TAM; PD-L1; Immune response; TUMOR-ASSOCIATED MACROPHAGES; T-CELL RESPONSES; BONE-MARROW; INFILTRATING MACROPHAGES; EXTRACELLULAR VESICLES; DENDRITIC CELLS; MYELOID CELLS; MONOCYTES; POLARIZATION; EXPRESSION;
D O I：
10.1007/s13577-021-00514-2
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Malignant tumors comprise various types of normal cells and tumor cells, and are infiltrated by large numbers of immune cells, including macrophages. The results of numerous studies on the function and significance of intratumoral macrophages (tumor-associated macrophages) suggest that these macrophages generally enhance tumor progression rather than act as anti-tumor immune agents. Although much remains unknown, in this review, we attempt to describe the role of macrophages in the tumor microenvironment, and discuss their potential mechanisms on the recent immunotherapy.
引用
收藏
页码：1031 / 1039
页数：9
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