Splanchnic ischemia and reperfusion injury is reduced by genetic or pharmacological inhibition of TNF-α

被引：0
|
作者：
Esposito, E. [1 ,3 ]
Mazzon, E. [2 ,3 ]
Muia, C. [2 ]
Meli, R. [1 ]
Sessa, E. [3 ]
Cuzzocrea, E. [2 ]
Cuzzocrea, S. [2 ,3 ]
机构：
[1] Univ Naples Federico II, Dept Expt Pharmacol, Naples, Italy
[2] Univ Messina, Sch Med, Dept Clin & Expt Med & Pharmacol, Messina, Italy
[3] IRCCS Ctr Neurolesi Bonino Pulejo, Messina, Italy
来源：
PROCEEDINGS OF THE 7TH WORLD CONGRESS ON TRAUMA, SHOCK, INFLAMMATION AND SEPSIS | 2007年
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D O I：
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中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
In the present study, we used TNF-alpha receptor 1 knockout mice to evaluate a possible role of TNF-alpha on the pathogenesis of ischen-tia and reperfusion injury of the multivisceral organs. In addition, we investigated the effect of Etanercept on this animal model system of inflammation. The genetic or pharmacological inhibition of TNF-alpha exerts a protective effect against the pathological changes caused by SAO/R.
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页码：63 / +
页数：2
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