Crystal Structure of Medicinal Product Triazavirin

被引：6
|
作者：
Voinkov, E. K. [1 ]
Drokin, R. A. [1 ]
Ulomskiy, E. N. [1 ,2 ]
Slepukhin, P. A. [2 ]
Rusinov, V. L. [1 ,2 ]
Chupakhin, O. N. [1 ,2 ]
机构：
[1] Ural Fed Univ, Dept Organ & Biomol Chem, 19 Mira St, Ekaterinburg 620002, Russia
[2] RAS, Inst Organ Synth, Ural Div, 22-20 S Kovalevskoy St,Akad Skaya St, Ekaterinburg 620990, Russia
来源：
JOURNAL OF CHEMICAL CRYSTALLOGRAPHY | 2019年 / 49卷 / 04期
基金：
俄罗斯科学基金会;
关键词：
Triazavirin; Antiviral; Triazolotriazine; Drug; Thermogravimetry; PROPHYLACTIC EFFICACY; INFLUENZA-VIRUS; ENCEPHALITIS;
D O I：
10.1007/s10870-018-0750-2
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
The X-ray data of 2-methylsulfanyl-6-nitro-1,2,4-triazolo [5,1-c][1,2,4]triazin-7-one sodium salt dihydrate (triazavirin) is reported. The compound crystallizes in the form binuclear complex ?? triclinic space group P-1 with unit cell parameters: a=7.2616 (6) angstrom, b=9.3036 (5) angstrom, c=9.5237 (7) angstrom, alpha=110.968 (6), beta=92.600 (6)degrees, gamma=102.990 (6)degrees and Z=1. [GRAPHICS] . Graphical AbstractInteraction of 3-(methylsulfanyl)-1H-1,2,4-triazole-5-diazonium hydrochloride with ethyl nitroacetate in sodium carbonate solution resulted in the formation of centrosymmetric binuclear complex of 2-methylsulfanyl-6-nitro-1,2,4-triazolo[5,1-c][1,2,4]triazin-7-one sodium salt dihydrate (triazavirin), which was structurally characterized.
引用
收藏
页码：213 / 218
页数：6
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