This paper analyses what vulnerability means and how it affects subjects and groups, highlighting its limits and potentialities given the intersectionality that can arise in many cases, especially in relation to race, gender, and class. To this end, the article is structured in three large blocks: The first, is an approximation to the concept of vulnerability and vulnerable groups; in the second, the type of specific situations are considered through the approach of intersectionality, especially with regard to race, gender and class, with an appreciation of the relationship between the systemic causes of discrimination and the group; and in the third and final block, a series of proposals are made and conclusions drawn. All this is examined from the inflections of thought, legal norms and political and regulatory agendas.