Improved synthesis of 2,3-dibromo-1-(phenylsulfonyl)-1-propene (DBP)

被引：3

作者：

VanZanten, A ^{[1
]}

Mullaugh, K ^{[1
]}

Harrington, R ^{[1
]}

Kiefer, A ^{[1
]}

Carlson, D ^{[1
]}

Mastarone, D ^{[1
]}

Lipchik, C ^{[1
]}

Murphree, SS ^{[1
]}

机构：

[1] Allegheny Coll, Dept Chem, Meadville, PA 16335 USA

来源：

SYNTHESIS-STUTTGART | 2004年 / 16期

关键词：

sulfones; halogenation; alkynes; allenes; thiols;

D O I：

10.1055/s-2004-831230

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient preparation of 2,3-dibromo-1-(phenylsulfonyl)-1-propene (DBP, 1) is available through the one-pot propargylation and oxidation of thiophenol to give the propargyl sulfone 11, which is isomerized and brominated in another one-pot reaction. The new preparation is significantly more scalable, as well as more convenient and robust than the prior art.

引用

页码：2611 / 2613

页数：3

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