Cerebral quantification of N-acetyl aspartate, aspartate, and glutamate levels in local structures of the human brain using J-editing of 1H magnetic resonance spectra in vivo

被引：7
|
作者：
Menshchikov, P. E. [1 ,2 ]
Semenova, N. A. [1 ,2 ,3 ]
Manzhurtsev, A. V. [2 ,3 ]
Akhadov, T. A. [1 ]
Varfolomeev, S. D. [3 ]
机构：
[1] Russian Acad Sci, NN Semenov Inst Chem Phys, 4 Ul Kosygina, Moscow 119334, Russia
[2] Sci Res Inst Emergency Childrens Surg & Traumatol, 22 Ul Bolshaya Polyanka, Moscow 119180, Russia
[3] Russian Acad Sci, NM Emanuel Inst Biochem Phys, 4 Ul Kosygina, Moscow 119334, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2018年 / 67卷 / 04期
基金：
俄罗斯基础研究基金会;
关键词：
H-1; MRS; MEGA-PRESS; aspartate; glutamate; H-1 MRS spectral J-editing; ACIDIC DIPEPTIDASE ACTIVITY; RAT-BRAIN; MR SPECTROSCOPY; NERVOUS-SYSTEM; DISTRIBUTIONS; INFARCTION; HEALTHY; H-1-MRS; STROKE; ENZYME;
D O I：
10.1007/s11172-018-2119-2
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A procedure was developed for the first time for simultaneous in vivo quantification of local aspartate and glutamate concentrations in the human brain using H-1 magnetic resonance spectroscopy (H-1 MRS) and spectral J-editing. The MEGA-PRESS pulse sequence was modified to observe beta-CH2 nonequivalent proton resonances of aspartate (delta 2.65 and 2.80) and glutamate (delta 2.04 and 2.12) overlapped by signals of other metabolites. The frequencies, frequency selective pulse durations, and optimal echo times were selected by simulation and experimentally (for phantoms and in the brain in vivo).
引用
收藏
页码：655 / 662
页数：8
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