The Roles of CD147 and/or Cyclophilin A in Kidney Diseases

被引：32
|
作者：
Qu, Xin [1 ,2 ]
Wang, Chunting [1 ]
Zhang, Jicheng [1 ]
Qie, Guoqiang [1 ]
Zhou, Jianxin [2 ]
机构：
[1] Shandong Univ, Shandong Prov Hosp, Dept Crit Care Med, Jinan 250021, Peoples R China
[2] Capital Med Univ, Beijing Tiantan Hosp, Dept Crit Care Med, Beijing 100050, Peoples R China
来源：
MEDIATORS OF INFLAMMATION | 2014年 / 2014卷
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
MATRIX METALLOPROTEINASE INDUCER; IMMUNOGLOBULIN SUPERFAMILY; THERAPEUTIC TARGET; CELL-PROLIFERATION; GLYCOPROTEIN CE9; MOUSE BASIGIN; RAT OX-47; EMMPRIN; EXPRESSION; INFLAMMATION;
D O I：
10.1155/2014/728673
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
CD147 is a widely expressed integral plasma membrane glycoprotein and has been involved in a variety of physiological and pathological activities in combination with different partners, including cyclophilins, caveolin-1, monocarboxylate transporters, and integrins. Recent data demonstrate that both CyPA and CD147 significantly contribute to renal inflammation, acute kidney injury, renal fibrosis, and renal cell carcinoma. Here we review the current understanding of cyclophilin A and CD147 expression and functions in kidney diseases and potential implications for treatment of kidney diseases.
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页数：10
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