CTCF fences make good neighbours

被引：8

作者：

Krivega, Ivan ^{[1
]}

Dean, Ann ^{[1
]}

机构：

[1] NIDDK, Lab Cellular & Dev Biol, NIH, Bethesda, MD 20892 USA

来源：

NATURE CELL BIOLOGY | 2017年 / 19卷 / 08期

关键词：

CHROMATIN INTERACTIONS; GENOME; DOMAINS;

D O I：

10.1038/ncb3584

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

CCCTC-binding factor (CTCF) sites are enriched at the boundaries of topologically associated domains (TADs), but their function within TADs is unclear. Removal of sub-TAD CTCF sites adjacent to the alpha-globin enhancers is now shown to result in inappropriate activation of neighbouring genes. Intra-TAD enhancer insulation might be broadly important for tissue specificity of enhancers.

引用

页码：883 / 885

页数：3

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