CTCF fences make good neighbours

被引：8
|
作者：
Krivega, Ivan [1 ]
Dean, Ann [1 ]
机构：
[1] NIDDK, Lab Cellular & Dev Biol, NIH, Bethesda, MD 20892 USA
来源：
NATURE CELL BIOLOGY | 2017年 / 19卷 / 08期
关键词：
CHROMATIN INTERACTIONS; GENOME; DOMAINS;
D O I：
10.1038/ncb3584
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
CCCTC-binding factor (CTCF) sites are enriched at the boundaries of topologically associated domains (TADs), but their function within TADs is unclear. Removal of sub-TAD CTCF sites adjacent to the alpha-globin enhancers is now shown to result in inappropriate activation of neighbouring genes. Intra-TAD enhancer insulation might be broadly important for tissue specificity of enhancers.
引用
收藏
页码：883 / 885
页数：3
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