Generation of integration-free induced pluripotent stem cell lines from four pediatric ADHD patients

被引：6

作者：

Grossmann, Leoni ^{[1
]}

Ohki, Cristine Marie Yde ^{[1
]}

Doering, Christian ^{[1
]}

Hoffmann, Per ^{[2
,3
,4
]}

Herms, Stefan ^{[2
,3
,4
]}

Werling, Anna Maria ^{[1
]}

Walitza, Susanne ^{[1
,5
,6
]}

Gruenblatt, Edna ^{[1
,5
,6
,7
]}

机构：

[1] Univ Zurich, Psychiat Univ Hosp Zurich, Dept Child & Adolescent Psychiat & Psychotherapy, Wagist 12, CH-8952 Zurich, Switzerland

[2] Univ Basel, Human Genom Res Grp, Dept Biomed, CH-4031 Basel, Switzerland

[3] Univ Bonn, Inst Human Genet, Sch Med, D-53105 Bonn, Germany

[4] Univ Hosp Bonn, D-53105 Bonn, Germany

[5] Univ Zurich, Neurosci Ctr Zurich, Zurich, Switzerland

[6] Swiss Fed Inst Technol, Zurich, Switzerland

[7] Univ Zurich, Zurich Ctr Integrat Human Physiol, Zurich, Switzerland

来源：

STEM CELL RESEARCH | 2021年 / 53卷

关键词：

D O I：

10.1016/j.scr.2021.102268

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Human induced pluripotent stem cell (iPSC) lines have been derived from four male patients with childhood attention-deficit hyperactivity disorder (ADHD). Children and adolescents between the ages 6 and 18 suffering from ADHD were recruited for this work. Isolated keratinocytes or peripheral blood mononuclear cells from the participants were reprogrammed into iPSCs using non-integrating Sendai virus to deliver the reprogramming factors Oct3/4, Sox2, Klf4 and c-Myc.

引用

页数：4

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