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Nankai Univ, Coll Life Sci, Inst Mol Biol,Minist Educ, Dept Canc Res,Key Lab Mol Microbiol & Technol, Tianjin 300071, Peoples R China Nankai Univ, Coll Life Sci, Inst Mol Biol,Minist Educ, Dept Canc Res,Key Lab Mol Microbiol & Technol, Tianjin 300071, Peoples R China