Th1/17 cells, a subset of Th17 cells, are expanded in patients with active systemic lupus erythematosus

被引：26

作者：

Tsanaktsi, Anastasia ^{[1
]}

Solomou, Elena E. ^{[2
]}

Liossis, Stamatis-Nick C. ^{[1
]}

机构：

[1] Univ Patras, Med Sch, Dept Internal Med, Div Rheumatol, Patras, Greece

[2] Univ Patras, Med Sch, Dept Internal Med, Patras, Greece

来源：

CLINICAL IMMUNOLOGY | 2018年 / 195卷

关键词：

IL-17-PRODUCING T-CELLS; FATE;

D O I：

10.1016/j.clim.2018.08.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Skewed cytokine production characterizes T cells in Systemic Lupus Erythematosus (SLE). Among Th17 cells that are expanded in lupus, a subset (Th1/17) retains the ability to produce IFN gamma. We aimed to analyze Th17 and Th1/17 cells in patients with SLE. Patients with active disease displayed increased percentages of circulating Th17 and Th1/17 cells. Stimulated T cells from patients with lupus secreted significantly more IL-17 compared to healthy donors. Also, T cells from patients with active SLE released significantly lower levels of IFN-gamma compared to controls. However, following stimulation, levels of IFN-gamma also rose significantly. Our data suggest that lupus Th1/17 cells are not only expanded but also functional. In summary, in this study it was shown that patients with active SLE display increased Th17 and functional Th1/17 cells. This impaired T-cell axis might represent a possible future therapeutic target.

引用

页码：101 / 106

页数：6

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