The action of insulin on cardiac contractility in active, hibernating and arousing ground squirrels

被引：0
|
作者：
Nakipova, OV [1 ]
Gainullin, RZ
Safronova, VG
Kosarsky, LS
Bakaneva, VF
Ignatiev, DA
Amerkhanov, ZG
Kolaeva, SG
Kukushkin, NI
Solomonov, NG
机构：
[1] Russian Acad Sci, Inst Cell Biophys, Pushchino 142292, Moscow Region, Russia
[2] Russian Acad Sci, Siberian Div, Inst Biol, Yakutsk, Russia
来源：
BIOFIZIKA | 1997年 / 42卷 / 06期
关键词：
D O I：
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中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
During the deep hibernation (at 5-6 degrees C of the heart temperature) and during arousal from hibernation (at 15-16 degrees C) insulin have no effect on contractility. Two opposite inotropic effects of insulin at concentrations 0,1-50 nM were found at higher temperature of arousing: a transient positive inotropic effect between 21-28 degrees C, and a negative one (about 20-30% from the control value) above 28 degrees C. In active summer and winter animals insulin produced mainly the negative inotropic effect.
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页码：1297 / 1300
页数：4
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