An update on catalytic enantioselective alkylations of indoles

被引：20
|
作者：
Bandini, Marco [1 ]
Eichholzer, Astrid [1 ]
Umani-Ronchi, Achille [1 ]
机构：
[1] Dipartimento Chim G Ciamician, I-40126 Bologna, Italy
来源：
MINI-REVIEWS IN ORGANIC CHEMISTRY | 2007年 / 4卷 / 02期
关键词：
alkylation; asymmetric catalysis; Friedel-Crafts; indoles;
D O I：
10.2174/157019307780599270
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Indole benzylic stereocenters are molecular frameworks largely present in natural occurring compounds, with their absolute configuration being of key importance in determining the biological activity of the entire molecule. In this context, the development of new catalytic asymmetric strategies for their preparation is a research area of astonishingly, rapid growth by means of organic as well as organometallic catalysts. Here, an update of this thriving scenario is presented by focusing in highly stereocontrolled Michael addition approaches, addition to carbonyl units, direct aromatic C-H activation/alkylation, and allylic alkylation.
引用
收藏
页码：115 / 124
页数：10
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