Organocatalyzed synthesis of chiral non-racemic 1,4-dihydropyridazines

被引：23

作者：

Pitacco, Giuliana ^{[1
]}

Attanasi, Orazio A. ^{[2
]}

De Crescentini, Lucia ^{[2
]}

Favi, Gianfranco ^{[2
]}

Felluga, Fulvia ^{[1
]}

Forzato, Cristina ^{[1
]}

Mantellini, Fabio ^{[2
]}

Nitti, Patrizia ^{[1
]}

Valentin, Ennio ^{[1
]}

Zangrando, Ennio ^{[1
]}

机构：

[1] Univ Trieste, Dipartimento Sci Chim, I-34127 Trieste, Italy

[2] Univ Urbino, Ist Chim Organ, I-61029 Urbino, Italy

来源：

TETRAHEDRON-ASYMMETRY | 2010年 / 21卷 / 05期

关键词：

CATALYZED MICHAEL ADDITION; ASYMMETRIC MICHAEL; STRAIGHTFORWARD ENTRY; ALDOL REACTIONS; KETONES; ALDEHYDES; ACID; 1,2-DIAZA-1,3-BUTADIENES; AMINOCARBONYLAZOALKENES; NITROALKENES;

D O I：

10.1016/j.tetasy.2010.03.007

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Chiral non-racemic 1,4-dihydropyridazines were prepared by the reaction of 1,2-diaza-1,3-dienes with arylacetaldehydes under organocatalytic conditions. L-Proline and (S)-(+)-1-(2-pyrrolidinylmethyl)pyrrolidine coupled with trifluoroacetic acid were used as organocatalysts. Enantiomeric excesses ranged from 25% to 78%. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：617 / 622

页数：6

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