In vivo treatment with a subacute low dose of 3-nitropropionic acid does not induce genotoxicity or mutagenicity in rats

被引：3

作者：

Techera Antunes, Flavia Tasmin ^{[1
]}

Caminski, Emanuelle Sistherenn ^{[2
]}

Picada, Jaqueline Nascimento ^{[3
]}

Regner, Andrea Pereira ^{[1
]}

Dallegrave, Eliane ^{[2
]}

de Souza, Alessandra Hubner ^{[1
]}

机构：

[1] Lutheran Univ Brazil ULBRA, Program Postgrad Cellular & Mol Biol Appl Hlth, Canoas, RS, Brazil

[2] Fed Univ Sci Hlth Porto Alegre UFCSPA, Dept Pharmacosci, Porto Alegre, RS, Brazil

[3] Univ Luterana Brasil, Lab Genet Toxicol, Canoas, RS, Brazil

来源：

TOXICON | 2021年 / 195卷

关键词：

Micronucleus; Comet assay; Polychromatic erythrocytes; Huntington's disease;

D O I：

10.1016/j.toxicon.2021.03.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

3-nitropropionic acid (3-NP) is a toxin that causes neural damage in the striatum and can lead to the development of Huntington's disease manifestations in animal models. Several studies have shown genotoxicity related to the 3-NP treatment. This study investigated potential genotoxicity and mutagenicity that was induced by a low dose (6.25 mg/kg i.p.) 3-NP subacute treatment (daily, over 6 days) in a rat model. The arterial blood and the frontal cortex were analyzed by the comet assay and the bone marrow by micronucleus. Surprisingly, the 3-NP subacute treatment with the low dose did not show genotoxic or mutagenic effects.

引用

页码：20 / 23

页数：4

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