In vivo treatment with a subacute low dose of 3-nitropropionic acid does not induce genotoxicity or mutagenicity in rats

被引：3
|
作者：
Techera Antunes, Flavia Tasmin [1 ]
Caminski, Emanuelle Sistherenn [2 ]
Picada, Jaqueline Nascimento [3 ]
Regner, Andrea Pereira [1 ]
Dallegrave, Eliane [2 ]
de Souza, Alessandra Hubner [1 ]
机构：
[1] Lutheran Univ Brazil ULBRA, Program Postgrad Cellular & Mol Biol Appl Hlth, Canoas, RS, Brazil
[2] Fed Univ Sci Hlth Porto Alegre UFCSPA, Dept Pharmacosci, Porto Alegre, RS, Brazil
[3] Univ Luterana Brasil, Lab Genet Toxicol, Canoas, RS, Brazil
来源：
TOXICON | 2021年 / 195卷
关键词：
Micronucleus; Comet assay; Polychromatic erythrocytes; Huntington's disease;
D O I：
10.1016/j.toxicon.2021.03.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
3-nitropropionic acid (3-NP) is a toxin that causes neural damage in the striatum and can lead to the development of Huntington's disease manifestations in animal models. Several studies have shown genotoxicity related to the 3-NP treatment. This study investigated potential genotoxicity and mutagenicity that was induced by a low dose (6.25 mg/kg i.p.) 3-NP subacute treatment (daily, over 6 days) in a rat model. The arterial blood and the frontal cortex were analyzed by the comet assay and the bone marrow by micronucleus. Surprisingly, the 3-NP subacute treatment with the low dose did not show genotoxic or mutagenic effects.
引用
收藏
页码：20 / 23
页数：4
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