Deciphering Heteroresistance to Colistin in a Klebsiella pneumoniae Isolate from Marseille, France

被引：2

作者：

Bardet, Lucie ^{[1
]}

Baron, Sophie ^{[1
]}

Leangapichart, Thongpan ^{[1
]}

Okdah, Liliane ^{[1
]}

Diene, Seydina M. ^{[1
]}

Rolain, Jean-Marc ^{[1
]}

机构：

[1] Aix Marseille Univ, CNRS 7278, INSERM 1095,IHU Med Infect, Fac Med & Pharm,UM63,IRD 198,IRD 198,URMITE, Marseille, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 06期

关键词：

Klebsiella pneumoniae; heteroresistance; colistin; mgrB; ACINETOBACTER-BAUMANNII; ENTEROBACTER-CLOACAE; AGAR DILUTION; RESISTANCE; INACTIVATION; EMERGENCE; MGRB; REGULATOR; EVOLUTION; OUTBREAK;

D O I：

10.1128/AAC.00356-17

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Here, we report the description of a colistin-heteroresistant Klebsiella pneumoniae isolate fortuitously isolated from the stool sample of a patient with suspicion of tuberculosis in a public hospital of Marseille, France. In the colistin-resistant subpopulation, a mutation in the mgrB gene leading to a premature stop codon was found, and the hypermucoviscous phenotype was lost. Susceptibility to other antibiotics remained unchanged. To our knowledge, this is the first identification of such a colistin-heteroresistant Klebsiella pneumoniae isolate in France.

引用

页数：5

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