REGIOSELECTIVE SYNTHESIS OF 2,4-DIFFERENTIALLY ARYLATED PYRROLES AND ITS APPLICATION TO THE SYNTHESIS OF LAMELLARINS

被引：6
|
作者：
Fukuda, Tsutomu [1 ]
Anzai, Mizuho [1 ]
Iwao, Masatomo [1 ]
机构：
[1] Nagasaki Univ, Grad Sch Engn, Div Chem & Mat Sci, 1-14 Bunkyo Machi, Nagasaki 8528521, Japan
来源：
HETEROCYCLES | 2016年 / 93卷 / 02期
关键词：
ALPHA 20-SULFATE ANALOGS; G TRIMETHYL ETHER; BIOLOGICAL-ACTIVITY; CATALYZED TRANSANNULATION; ANTITUBERCULAR AGENTS; EFFICIENT SYNTHESIS; MODULAR SYNTHESIS; TERMINAL ALKYNES; DERIVATIVES; ALKALOIDS;
D O I：
10.3987/COM-15-S(T)49
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method for the synthesis of 2,4-differentially arylated pyrroles has been developed via stepwise palladium-catalyzed Suzuki-Miyaura coupling of N-benzenesulfonyl-4-bromo-2-iodopyrrole with different arylboronic acids. This method has been applied to the new synthesis of the marine natural products lamellarins.
引用
收藏
页码：593 / 612
页数：20
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