Daily spirometry in an acute exacerbation of adult cystic fibrosis patients

被引：3

作者：

Stephen, Michael J. ^{[1
]}

Long, Alex ^{[2
]}

Bonsall, Chad ^{[3
]}

Hoag, Jeffrey B. ^{[1
]}

Shah, Smita ^{[4
]}

Bisberg, Dorothy ^{[4
]}

Holsclaw, Douglas ^{[3
]}

Varlotta, Laurie ^{[5
]}

Fiel, Stan ^{[6
]}

Du, Doantrang ^{[7
]}

Zanni, Robert ^{[7
]}

Hadjiliadis, Denis ^{[3
]}

机构：

[1] Drexel Univ, Sch Med, Div Pulm & Crit Care, Philadelphia, PA USA

[2] Drexel Univ, Sch Publ Hlth, Philadelphia, PA USA

[3] Univ Penn, Div Pulm & Crit Care, Philadelphia, PA USA

[4] Pediat Specialty Ctr, St Barnabas Med Ctr, Barnabas Hlth Med Grp, W Orange, NJ USA

[5] St Christophers Hosp Children, Philadelphia, PA USA

[6] Atlantic Hlth Syst, Morristown, NJ USA

[7] Monmouth Med Ctr, Long Branch, NJ USA

来源：

CHRONIC RESPIRATORY DISEASE | 2018年 / 15卷 / 03期

关键词：

Cystic fibrosis; acute exacerbation; home spirometry; CFQ-R; intravenous antibiotics; QUALITY-OF-LIFE; PULMONARY EXACERBATIONS; RESPIRATORY EXACERBATIONS; ANTIBIOTIC-TREATMENT; MORTALITY; OUTCOMES;

D O I：

10.1177/1479972317743756

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

To help answer the question of length of intravenous antibiotics during an acute exacerbation of cystic fibrosis (CF), we had subjects to follow daily home spirometry while on intravenous antibiotics. CF patients, 18 and older, with an acute exacerbation requiring intravenous antibiotics had a daily FEV1. The average time to a 10% increase over their initial sick FEV1 was calculated, as well as the time to a new baseline. A total of 25 subjects completed the study. Ten of the 25 subjects did not have a sustainable 10% increase in FEV1. Of the 15 subjects with a sustainable 10% increase in FEV1, it took 5.2 days (+/- 4.5) after day 1, while a new baseline was achieved on average at 6.6 days (+/- 4.8) after day 1. Given the wide range of time to a 10% improvement and new baseline, it is recommended there should be flexibility in length of intravenous antibiotics in CF, not by a preset number.

引用

页码：258 / 264

页数：7

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