Review: The ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration

被引：0
|
作者：
Rogers, N. [1 ]
Paine, S. [1 ]
Bedford, L. [1 ]
Layfield, R. [1 ]
机构：
[1] Univ Nottingham, Sch Med, Queens Med Ctr, Sch Biomed Sci, Nottingham NG7 2UH, England
来源：
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY | 2010年 / 36卷 / 02期
关键词：
neurodegeneration; Parkinson's disease; proteasome; ubiquitin; FAMILIAL PARKINSONS-DISEASE; ALPHA-SYNUCLEIN PHOSPHORYLATION; CHAPERONE-MEDIATED AUTOPHAGY; TERMINAL HYDROLASE L1; LEWY BODIES; ALZHEIMERS-DISEASE; TYROSINE-HYDROXYLASE; AGGRESOME FORMATION; PROTEOLYTIC STRESS; DROSOPHILA MODEL;
D O I：
10.1111/j.1365-2990.2009.01063.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The significance of the accumulation of ubiquitin-positive intraneuronal inclusions in the brains of those affected with different neurodegenerative diseases is currently unclear. While one interpretation is that the disease mechanism(s) involves dysfunction of an ubiquitin-mediated process, such as the ubiquitin-proteasome system, the inclusions are also found in surviving neurones, suggesting a possible neuroprotective role. Here we review recent evidence in support of these seemingly opposing notions gleaned from cell and animal models as well as investigations of patient samples, with particular emphasis on studies relevant to Parkinson's disease.
引用
收藏
页码：113 / 124
页数：12
相关论文
共 50 条
  • [21] The nuclear ubiquitin-proteasome system
    von Mikecz, Anna
    JOURNAL OF CELL SCIENCE, 2006, 119 (10) : 1977 - 1984
  • [22] Ubiquitin-proteasome system - Ubiquitin-free routes into the proteasome
    Hoyt, MA
    Coffino, P
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2004, 61 (13) : 1596 - 1600
  • [23] The Ubiquitin-Proteasome System in Apoptosis and Apoptotic Cell Clearance
    Yuan, Lei
    Li, Peiyao
    Zheng, Qian
    Wang, Hui
    Xiao, Hui
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 10
  • [24] Coordination of cell growth and division by the ubiquitin-proteasome system
    Benanti, Jennifer A.
    SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2012, 23 (05) : 492 - 498
  • [25] Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin-proteasome system
    McKinnon, Chris
    Goold, Rob
    Andre, Ralph
    Devoy, Anny
    Ortega, Zaira
    Moonga, Julie
    Linehan, Jacqueline M.
    Brandner, Sebastian
    Lucas, Jose J.
    Collinge, John
    Tabrizi, Sarah J.
    ACTA NEUROPATHOLOGICA, 2016, 131 (03) : 411 - 425
  • [26] Regulation of the endothelial cell cycle by the ubiquitin-proteasome system
    Fasanaro, Pasquale
    Capogrossi, Maurizio C.
    Martelli, Fabio
    CARDIOVASCULAR RESEARCH, 2010, 85 (02) : 272 - 280
  • [27] The ubiquitin-proteasome system in glioma cell cycle control
    Vlachostergios, Panagiotis J.
    Voutsadakis, Ioannis A.
    Papandreou, Christos N.
    CELL DIVISION, 2012, 7
  • [28] The ubiquitin-proteasome system in glioma cell cycle control
    Panagiotis J Vlachostergios
    Ioannis A Voutsadakis
    Christos N Papandreou
    Cell Division, 7
  • [29] The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy
    Kwon, Yong Tae
    Ciechanover, Aaron
    TRENDS IN BIOCHEMICAL SCIENCES, 2017, 42 (11) : 873 - 886
  • [30] Cell biology of the neuron: Untangling the ubiquitin-proteasome system
    Lewis S.
    Nature Reviews Neuroscience, 2018, 19 (4) : 184 - 184
12345