CDCA2 promotes tumorigenesis and induces radioresistance in oesophageal squamous cell carcinoma cells

被引：6
|
作者：
Xu, Bing [1 ]
Chen, Hui [1 ]
Xu, Zhipeng [2 ]
Yao, Xijuan [1 ]
Sun, Xinchen [1 ]
Cheng, Hongyan [3 ]
机构：
[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Radiat Oncol, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China
[2] Southeast Univ, Affiliated Zhongda Hosp, Dept Urol, Nanjing 210009, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Affiliated Hosp 1, Dept Synthet Internal Med, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China
来源：
MOLECULAR MEDICINE REPORTS | 2021年 / 24卷 / 01期
基金：
中国国家自然科学基金;
关键词：
tumorigenesis; radiosensitivity; The Cancer Genome Atlas; DNA repair; gene set enrichment analysis; cell cycle phase; CANCER-CELLS; DNA-REPAIR; CYCLE; SENSITIVITY; EXPRESSION; BIOMARKERS; CHROMATIN; GENES;
D O I：
10.3892/mmr.2021.12169
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cell division cycle-associated 2 (CDCA2) overexpression has been demonstrated to serve a significant role in tumorigenesis in certain types of cancer. Nevertheless, its role in tumour proliferation and radioresistance in oesophageal squamous cell carcinoma (ESCC) remains to be elucidated. Thus, the present study aimed to elucidate these roles. Data were downloaded from The Cancer Genome Atlas (TCGA) to compare the gene expression profiles. The expression of CDCA2 was higher in ESCC tissues compared with normal tissues. Gene set enrichment analysis was performed based on the ESCC cohorts in TCGA database. This demonstrated that higher expression of CDCA2 was significantly associated with the expression of related components of the cell cycle phase transition and G(2)/M phase transition pathways. Collectively, the results revealed that CDCA2 could serve as an underlying target to regulate tumour growth and radioresistance among patients with ESCC.
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页数：10
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