The study of distribution of ingested terbinafine on skin with ambient ionization tandem mass spectrometry

被引：5

作者：

Cho, Yi-Tzu ^{[1
]}

Su, Hung ^{[2
]}

Wu, Ching-Ying ^{[3
]}

Jeng, Jingyueh ^{[4
,5
,6
]}

Lee, Chi-Wei ^{[7
]}

Wu, Deng-Chyang ^{[8
,9
,10
]}

Huang, Tiao-Lai ^{[11
,12
,13
]}

Shiea, Jentaie ^{[2
,14
,15
]}

机构：

[1] Yuh Ing Jr Coll Hlth Care & Management, Dept Cosmet Applicat & Management, 15 Ln,420 Dachang 2nd Rd, Kaohsiung 807634, Taiwan

[2] Natl Sun Yat Sen Univ, Dept Chem, 70 Lienhai Rd, Kaohsiung 804201, Taiwan

[3] Kaohsiung Med Univ, Coll Med, Dept Dermatol, Kaohsiung 807378, Taiwan

[4] Chia Nan Univ Pharm & Sci, Dept Med Chem, Tainan 717301, Taiwan

[5] Chia Nan Univ Pharm & Sci, Dept Cosmet Sci, Tainan 717301, Taiwan

[6] Chia Nan Univ Pharm & Sci, Inst Cosmet Sci, Tainan 717301, Taiwan

[7] Natl Sun Yat Sen Univ, Inst Med Sci & Technol, Kaohsiung 804201, Taiwan

[8] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Gastroenterol, Kaohsiung 807378, Taiwan

[9] Kaohsiung Med Univ, Regenerat Med & Cell Therapy Res Ctr, Kaohsiung 807378, Taiwan

[10] Kaohsiung Med Univ, Coll Med, Fac Med, Dept Med, Kaohsiung 807378, Taiwan

[11] Chang Gung Mem Hosp, Kaohsiung Med Ctr, Dept Psychiat, 123 Ta Pei Rd, Kaohsiung 833401, Taiwan

[12] Chang Gung Univ, Coll Med, 123 Ta Pei Rd, Kaohsiung 833401, Taiwan

[13] Kaohsiung Chang Gung Mem Hosp, Dept Med Res, Genom & Prote Core Lab, Kaohsiung 833401, Taiwan

[14] Kaohsiung Med Univ, Dept Med & Appl Chem, Kaohsiung 807378, Taiwan

[15] Kaohsiung Med Univ, Res Ctr Environm Med, Kaohsiung 807378, Taiwan

来源：

JOURNAL OF FOOD AND DRUG ANALYSIS | 2022年 / 30卷 / 02期

关键词：

Epidermis; Skin; Terbinafine; Thermal desorption-electrospray ionization tandem mass spectrometry; OF-CARE IDENTIFICATION; DERMIS-EPIDERMIS; STRATUM-CORNEUM; VOLATILE COMPOUNDS; ORAL FLUID; SWEAT; HAIR; SEBUM; DRUGS; PHARMACOKINETICS;

D O I：

10.38212/2224-6614.3413

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

We aim to develop an efficient and non-invasive strategy for monitoring of drugs and their metabolites via human skin. Probe sampling was combined with thermal desorption-electrospray ionization tandem mass spectrometry (TD-ESI/MS/MS) to characterize trace terbinafine, which was secreted on patient's skin after ingesting terbinafine tablets. The terbinafine ion signals were directly detected in the samples collected from different skin regions and the signals were monitored for 8 weeks. The detection and location of terbinafine via the skin suggest that the methods are useful in rapidly and noninvasively collecting the molecular information of the ingested drug on skin for pharmacokinetic studies.

引用

页码：303 / 315

页数：14

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