A pair of new tirucallane triterpenoid epimers from the stems of Picrasma quassioides

被引：0
|
作者：
Zhang Jie [1 ]
Wang Chuan-Xi [2 ]
Song Xiao-Jun [1 ]
Li Shuang [1 ]
Zhao Huan [2 ]
Chen Guo-Dong [2 ]
Hu Dan [2 ]
Gao Hao [1 ,2 ]
Yao Xin-Sheng [2 ]
机构：
[1] Shenyang Pharmaceut Univ, Coll Tradit Chinese Mat Med, Shenyang 110016, Peoples R China
[2] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China
来源：
CHINESE JOURNAL OF NATURAL MEDICINES | 2019年 / 17卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Tirucallane triterpenoid; Epimers; Picrasma quassioides; AChE inhibitory activity; Cytotoxicity; Antimicrobial activity;
D O I：
暂无
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
A pair of new tirucallane triterpenoid epimers, picraquassins M and N (1 and 2), were isolated from the stems of Picrasma quassioides (D. Don) Benn. Their structures were determined based on comprehensive spectroscopic and X-ray crystallographic analyses. In addition, their AChE inhibitory activity, cytotoxicity against five human tumour cell lines (SW480, MCF-7, HepG2, Hela, and PANC-1), and antimicrobial activity against two bacteria (Staphylococcus. aureus 209P and Escherichia coli ATCC0111) and two fungi (Candida albicans FIM709 and Aspergillus niger R330) were evaluated.
引用
收藏
页码：906 / 911
页数：6
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