Synthesis and functionalization of new tropanes designed for use as scaffolds in combinatorial chemistry

被引：1

作者：

Paparin, JL

Crévisy, C

Toupet, L

Grée, R

机构：

[1] ENSCR, UMR CNRS 6052, Lab Synth & Activat Biomol, F-35042 Rennes, France

[2] Univ Rennes 1, Grp Mat Condensee & Mat, F-35042 Rennes, France

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2000年 / 2000卷 / 23期

关键词：

cycloadditions; alkaloids; combinatorial chemistry; scaffolds; tropanes;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The [4+3] cycloaddition reaction between alkyloxycarbonyl-substituted pyrroles and alpha,alpha'-dibromo ketones in the presence of diethylzinc has been extended to a wide range of substrates. The functionalization of the resulting tropanes has been studied. It is demonstrated that such tropanes represent potentially useful scaffolds.

引用

页码：3909 / 3918

页数：10

共 50 条

[21] Solution phase combinatorial chemistry .1. Synthesis of polyazacyclophane scaffolds and tertiary amine libraries
An, HY
Cook, PD
TETRAHEDRON LETTERS, 1996, 37 (40) : 7233 - 7236
[22] Solution phase combinatorial chemistry - I. Synthesis of polyazacyclophane scaffolds and tertiary amine libraries
An, H.
Cook, P. D.
Tetrahedron Letters, 37 (40):
[23] Organic synthesis and combinatorial chemistry
Babaev, EV
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1999, (05): : 714 - 716
[24] AUTOMATED SYNTHESIS AND COMBINATORIAL CHEMISTRY
DEWITT, SH
CZARNIK, AW
CURRENT OPINION IN BIOTECHNOLOGY, 1995, 6 (06) : 640 - 645
[25] Combinatorial chemistry synthesis techniques
Vazquez, ML
PROCEEDINGS OF THE 19TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOL 19, PTS 1-6: MAGNIFICENT MILESTONES AND EMERGING OPPORTUNITIES IN MEDICAL ENGINEERING, 1997, 19 : 2662 - 2667
[26] Combinatorial chemistry -: Synthesis of β-lactams
Lloyd, AW
DRUG DISCOVERY TODAY, 1999, 4 (12) : 570 - 571
[27] An introduction to synthesis in combinatorial chemistry
Dean, M
CHIMICA OGGI-CHEMISTRY TODAY, 1998, 16 (11-12) : 73 - 75
[28] Combinatorial chemistry in organic synthesis
Takahashi, T
Doi, T
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 2002, 60 (05) : 426 - 433
[29] Synthesis and coordination properties of a new ligand designed for surface functionalization of carbon substrates
Savastano, Matteo
Zoppi, Carlotta
Bianchi, Antonio
Bazzicalupi, Carla
INORGANICA CHIMICA ACTA, 2020, 511 (511)
[30] Synthesis of combinatorial libraries based on terpenoid scaffolds
Pathak, A
Singh, SK
Biabani, MAF
Kulshreshtha, DK
Puri, SK
Srivastava, S
Kundu, B
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 2002, 5 (03) : 241 - 248

← 1 2 3 4 5 →