FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene

被引：362

作者：

Zuo, Tao

Wang, Lizhong

Morrison, Carl

Chang, Xing

Zhang, Huiming

Li, Weiquan

Liu, Yan

Wang, Yin

Liu, Xingluo

Chan, Michael W. Y.

Liu, Jin-Qing

Love, Richard

Liu, Chang-gong

Godfrey, Virginia

Shen, Rulong

Huang, Tim H. -M.

Yang, Tianyu

Park, Bae Keun

Wang, Cun-Yu

Zheng, Pan ^{[1
]}

Liu, Yang

机构：

[1] Univ Michigan, Ctr Comprehens Canc, Dept Surg, Sect Gen Surg,Div Immunotherapy, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Program Mol Mech Dis, Ann Arbor, MI 48109 USA

[3] Ohio State Univ, Med Ctr, Dept Virol Immunol & Med Genet, Program Mol Cellular & Dev Biol, Columbus, OH 43210 USA

[4] Ohio State Univ, Med Ctr, Dept Pathol, Columbus, OH 43210 USA

[5] Ohio State Univ, Med Ctr, Dept Internal Med, Columbus, OH 43210 USA

[6] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

[7] Univ N Carolina, Dept Pathol, Chapel Hill, NC 27599 USA

[8] Univ Michigan, Dept Biol & Mat Sci, Lab Mol Signaling & Apoptosis, Sch Dent, Ann Arbor, MI 48109 USA

来源：

CELL | 2007年 / 129卷 / 07期

关键词：

D O I：

10.1016/j.cell.2007.04.034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The X-linked Foxp3 is a member of the forkhead/winged helix transcription factor family. Germline mutations cause lethal autoimmune diseases in males. Serendipitously, we observed that female mice heterozygous for the "scurfin'' mutation of the Foxp3 gene (Foxp3(sf/+)) developed cancer at a high rate. The majority of the cancers were mammary carcinomas in which the wild-type Foxp3 allele was inactivated and HER-2/ErbB2 was overexpressed. Foxp3 bound and repressed the HER-2/ErbB2 promoter. Deletion, functionally significant somatic mutations, and downregulation of the FOXP3 gene were commonly found in human breast cancer samples and correlated significantly with HER-2/ErbB2 overexpression, regardless of the status of HER-2 amplification. Our data demonstrate that FOXP3 is an X-linked breast cancer suppressor gene and an important regulator of the HER-2/ErbB2 oncogene.

引用

页码：1275 / 1286

页数：12

共 50 条

[21] HER-2/neu oncogene amplification in breast cancer
Depowski, PL
Brien, TP
Sheehan, CE
Muraca, PJ
Stylos, S
Johnson, RL
Ross, JS
MODERN PATHOLOGY, 1998, 11 (01) : 18A - 18A
[22] MOLECULAR-CLONING AND SEQUENCING OF AN INTRON OF HER-2 NEU (ERBB2) GENE
SARKAR, FH
BALL, DE
LI, YW
CRISSMAN, JD
DNA AND CELL BIOLOGY, 1993, 12 (07) : 611 - 615
[23] Palindromic amplification of the ERBB2 oncogene in primary HER2-positive breast tumors
Michael Marotta
Taku Onodera
Jeffrey Johnson
G. Thomas Budd
Takaaki Watanabe
Xiaojiang Cui
Armando E. Giuliano
Atsushi Niida
Hisashi Tanaka
Scientific Reports, 7
[24] Palindromic amplification of the ERBB2 oncogene in primary HER2-positive breast tumors
Marotta, Michael
Onodera, Taku
Johnson, Jeffrey
Budd, G. Thomas
Watanabe, Takaaki
Cui, Xiaojiang
Giuliano, Armando E.
Niida, Atsushi
Tanaka, Hisashi
SCIENTIFIC REPORTS, 2017, 7
[25] ERBB2 oncogene in human breast cancer and its clinical significance
Révillion, F
Bonneterre, J
Peyrat, JP
EUROPEAN JOURNAL OF CANCER, 1998, 34 (06) : 791 - 808
[26] ErbB2/Her-2 regulates the expression of Akt2 in prostate cancer cells
Le Page, Cecile
Koumakpayi, Ismael Herve
Peant, Benjamin
Delvoye, Nathalie
Saad, Fred
Mes-Masson, Anne-Marie
PROSTATE, 2012, 72 (07): : 777 - 788
[27] ERBB2 mRNA expression in HER2-low breast cancer
Teng, X.
Li, X.
Xu, S.
Zhang, J.
Bai, Y.
Ba, X.
Wu, Z.
Liu, S.
EUROPEAN JOURNAL OF CANCER, 2022, 175 : S93 - S93
[28] HER-2/neu oncogene expression in advanced breast cancer
Krogerus, LA
Leivonen, M
CANCER DETECTION AND PREVENTION, 2001, 25 (01): : 1 - 7
[29] Treatment options in ErbB2 (HER2)-overexpressing breast cancer
Jackisch, Christian
BREAST CARE, 2008, 3 : 1 - 1
[30] Challenges in the treatment of ErbB2 (HER2)-positiive breast cancer
Jackisch, Christian
EJC SUPPLEMENTS, 2008, 6 (05): : 7 - 14

← 1 2 3 4 5 →