The genetics of ageing

被引：1997
|
作者：
Kenyon, Cynthia J. [1 ]
机构：
[1] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94158 USA
来源：
NATURE | 2010年 / 464卷 / 7288期
关键词：
LIFE-SPAN EXTENSION; RESTRICTION-INDUCED LONGEVITY; DIETARY RESTRICTION; CAENORHABDITIS-ELEGANS; C; ELEGANS; CALORIE RESTRICTION; MEDIATES LONGEVITY; SIGNALING PATHWAY; AUTOPHAGY GENES; INSULIN;
D O I：
10.1038/nature08980
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The nematode Caenorhabditis elegans ages and dies in a few weeks, but humans can live for 100 years or more. Assuming that the ancestor we share with nematodes aged rapidly, this means that over evolutionary time mutations have increased lifespan more than 2,000-fold. Which genes can extend lifespan? Can we augment their activities and live even longer? After centuries of wistful poetry and wild imagination, we are now getting answers, often unexpected ones, to these fundamental questions.
引用
收藏
页码：504 / 512
页数：9
相关论文
共 50 条
  • [21] The molecular genetics of human ageing and longevity
    Gonos, ES
    ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE, 1999, 32 (02): : 8 - 8
  • [22] Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing
    Tacutu, Robi
    Craig, Thomas
    Budovsky, Arie
    Wuttke, Daniel
    Lehmann, Gilad
    Taranukha, Dmitri
    Costa, Joana
    Fraifeld, Vadim E.
    de Magalhaes, Joao Pedro
    NUCLEIC ACIDS RESEARCH, 2013, 41 (D1) : D1027 - D1033
  • [23] To bud until death: The genetics of ageing in the yeast, Saccharomyces
    Austriaco, NR
    YEAST, 1996, 12 (07) : 623 - 630
  • [24] The genetics of ageing (vol 464, pg 504, 2010)
    Kenyon, Cynthia J.
    NATURE, 2010, 467 (7315) : 622 - 622
  • [25] The genetics and epigenetics of altered proliferative homeostasis in ageing and cancer
    Martin, George M.
    MECHANISMS OF AGEING AND DEVELOPMENT, 2007, 128 (01) : 9 - 12
  • [26] Mutation and the evolution of ageing: from biometrics to system genetics
    Hughes, Kimberly A.
    PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2010, 365 (1544) : 1273 - 1279
  • [27] Hormesis - a new hope for ageing studies or a poor second to genetics?
    Lithgow, GJ
    HUMAN & EXPERIMENTAL TOXICOLOGY, 2001, 20 (06) : 301 - 303
  • [28] The genetics of cognitive ability and cognitive ageing in healthy older people
    Harris, Sarah E.
    Deary, Ian J.
    TRENDS IN COGNITIVE SCIENCES, 2011, 15 (09) : 388 - 394
  • [29] Calcific Aortic Valve Disease: Insights Into the Genetics of Vascular Ageing
    Jeremy, Richmond W.
    CIRCULATION-CARDIOVASCULAR GENETICS, 2017, 10 (06)
  • [30] Evolutionary genetics of ageing in the wild: empirical patterns and future perspectives
    Wilson, A. J.
    Charmantier, A.
    Hadfield, J. D.
    FUNCTIONAL ECOLOGY, 2008, 22 (03) : 431 - 442
12345