Lack of response to imatinib mesylate in a patient with accelerated phase myeloproliferative disorder with rearrangement of the platelet-derived growth factor receptor β-gene

被引：0

作者：

Bastie, JN

Garcia, I

Terré, C

Cross, NCP

Mahon, FX

Castaigne, S

机构：

[1] Salisbury Dist Hosp, Dept Hematol & Oncol, Salisbury, Wilts, England

[2] Salisbury Dist Hosp, Dept Biochem Haematol & Cytogenet, Salisbury, Wilts, England

[3] Salisbury Dist Hosp, Wessex Reg Genet Lab, Salisbury, Wilts, England

[4] Univ Bordeaux 2, CNRS, Unite 2617, F-33076 Bordeaux, France

来源：

HAEMATOLOGICA | 2004年 / 89卷 / 10期

关键词：

atypical chronic myeloproliferative disorder; PDGFRB; t(5; 10); imatinib mesylate;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Imatinib mesylate has been reported to produce positive results in atypical chronic myeloproliferative disorders (CMD) with chromosomal translocations that disrupt the platelet-derived growth factor receptor (3 gene (PDGFRB). We used imatinib to treat a 49-year old man with atypical CMD in accelerated phase and the H4 (D10S170)-PDGFRB fusion gene. After 3 months of treatment, we observed grade 4 hematologic toxicity and a lack of response.

引用

页码：1263 / 1264

页数：2

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