Photoactivatable CO release from engineered protein crystals to modulate NF-κB activation

被引：25

作者：

Tabe, Hiroyasu ^{[1
]}

Shimoi, Takuya ^{[2
]}

Boudes, Marion ^{[3
,4
]}

Abe, Satoshi ^{[2
]}

Coulibaly, Fasseli ^{[3
,4
]}

Kitagawa, Susumu ^{[1
]}

Mori, Hajime ^{[5
]}

Ueno, Takafumi ^{[2
]}

机构：

[1] Kyoto Univ, Grad Sch Engn, Nishikyo Ku, Kyoto 6158510, Japan

[2] Tokyo Inst Technol, Grad Sch Biosci & Biotechnol, Midori Ku, Nagatsuta 4259, Yokohama, Kanagawa 2248501, Japan

[3] Monash Univ, Monash Biomed Discovery Inst, Infect & Immun Program, Melbourne, Vic 3800, Australia

[4] Monash Univ, Dept Biochem & Mol Biol, Melbourne, Vic 3800, Australia

[5] Kyoto Inst Technol, Insect Biomed Res Ctr, Sakyo Ku, Kyoto 6068585, Japan

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 24期

基金：

日本学术振兴会;

关键词：

CARBON-MONOXIDE; CYPOVIRUS POLYHEDRA; METAL-CARBONYLS; COMPLEXES; MOLECULES; DELIVERY; LIGHT; NO; NANOPARTICLES; BIOMATERIALS;

D O I：

10.1039/c5cc10440h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Photoactivatable CO releasing protein crystals were developed by immobilization of Mn carbonyl complexes in polyhedral crystals, which are spontaneously formed in insect cells. The photoactivatable CO release from the engineered protein crystals activates nuclear factor kappa B (NF-kappa B) upon stimulation by visible light irradiation with suppression of cytotoxicity of the Mn complex.

引用

页码：4545 / 4548

页数：4

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