One-step synthesis of hypoxanthine from glycinamide and diformylurea

被引：13
|
作者：
Lagoja, IM [1 ]
Herdewijn, P [1 ]
机构：
[1] Katholieke Univ Leuven, Rega Inst Med Res, Med Chem Lab, B-3000 Louvain, Belgium
来源：
CHEMISTRY & BIODIVERSITY | 2004年 / 1卷 / 01期
关键词：
D O I：
10.1002/cbdv.200490001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Because of their easy availability and their relative chemical stability, urea, formic acid, and glycine might have played a role in the assembly process of nucleobases. In this paper, a short reaction path is described to prepare hypoxanthine starting from the above mentioned precursors. The formation of hypoxanthine has been verified by high-resolution mass spectrometry with the N-15-labelled urea as starting material, and HPLC analysis. The yield of this condensation reaction has been determined spectrophotometrically.
引用
收藏
页码：106 / 111
页数：6
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