Susceptibility of Chickens to Low Pathogenic Avian Influenza (LPAI) Viruses of Wild Bird- and Poultry-Associated Subtypes

被引:15
|
作者
Bergervoet, Saskia A. [1 ,2 ]
Germeraad, Evelien A. [1 ]
Alders, Marc [1 ]
Roose, Marit M. [1 ]
Engelsma, Marc Y. [1 ]
Heutink, Rene [1 ]
Bouwstra, Ruth [3 ]
Fouchier, Ron A. M. [2 ]
Beerens, Nancy [1 ]
机构
[1] Wageningen Biovet Res, Dept Virol, NL-8200 AB Lelystad, Netherlands
[2] Erasmus MC, Dept Virosci, NL-3015 GD Rotterdam, Netherlands
[3] GD Anim Hlth Serv, NL-7418 EZ Deventer, Netherlands
来源
VIRUSES-BASEL | 2019年 / 11卷 / 11期
关键词
avian influenza virus; low pathogenic avian influenza; wild birds; poultry; chickens; shedding; innate immune response; MULTIPLE SEQUENCE ALIGNMENT; A VIRUS; PHYLOGENETIC ANALYSIS; GENE-EXPRESSION; HOST-RANGE; B-ALLELE; CD-HIT; DUCKS; RESPONSES; MARKETS;
D O I
10.3390/v11111010
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Analysis of low pathogenic avian influenza (LPAI) viruses circulating in the Netherlands in a previous study revealed associations of specific hemagglutinin (HA) and neuraminidase (NA) subtypes with wild bird or poultry hosts. In this study, we identified putative host associations in LPAI virus internal proteins. We show that LPAI viruses isolated from poultry more frequently carried the allele A variant of the nonstructural protein (NS) gene, compared to wild bird viruses. We determined the susceptibility of chickens to wild bird-associated subtypes H3N8 and H4N6 and poultry-associated subtypes H8N4 and H9N2, carrying either NS allele A or B, in an infection experiment. We observed variations in virus shedding and replication patterns, however, these did not correlate with the predicted wild bird- or poultry-associations of the viruses. The experiment demonstrated that LPAI viruses of wild bird-associated subtypes can replicate in chickens after experimental infection, despite their infrequent detection in poultry. Although the NS1 protein is known to play a role in immune modulation, no differences were detected in the limited innate immune response to LPAI virus infection. This study contributes to a better understanding of the infection dynamics of LPAI viruses in chickens.
引用
收藏
页数:17
相关论文
共 50 条
  • [21] Highly Pathogenic and Low Pathogenic Avian Influenza H5 Subtype Viruses in Wild Birds in Ukraine
    Muzyka, Denys
    Rula, Oleksandr
    Tkachenko, Semen
    Muzyka, Nataliia
    Koethe, Susanne
    Pishchanskyi, Oleksandr
    Stegniy, Borys
    Pantin-Jackwood, Mary
    Beer, Martin
    AVIAN DISEASES, 2019, 63 (01) : 219 - 229
  • [22] H5 low pathogenic avian influenza viruses maintained in wild birds in China
    Tian, Jingman
    Li, Minghui
    Bai, Xiaoli
    Li, Yulei
    Wang, Xuefeng
    Wang, Fuhong
    Shi, Jianzhong
    Zeng, Xianying
    Tian, Guobin
    Li, Yanbing
    VETERINARY MICROBIOLOGY, 2021, 263
  • [23] Evidence of the Presence of Low Pathogenic Avian Influenza A Viruses in Wild Waterfowl in 2018 in South Africa
    Poen, Marjolein J.
    Fouchier, Ron A. M.
    Webby, Richard J.
    Webster, Robert G.
    El Zowalaty, Mohamed E.
    PATHOGENS, 2019, 8 (04):
  • [24] Genetic analysis identifies potential transmission of low pathogenic avian influenza viruses between poultry farms
    Bergervoet, Saskia A.
    Heutink, Rene
    Bouwstra, Ruth
    Fouchier, Ron A. M.
    Beerens, Nancy
    TRANSBOUNDARY AND EMERGING DISEASES, 2019, 66 (04) : 1653 - 1664
  • [25] Genetic changes that accompanied shifts of low pathogenic avian influenza viruses toward higher pathogenicity in poultry
    Abdelwhab, El-Sayed M.
    Veits, Jutta
    Mettenleiter, Thomas C.
    VIRULENCE, 2013, 4 (06) : 441 - 452
  • [26] Susceptibility of wild passerines to subtype H5N1 highly pathogenic avian influenza viruses
    Fujimoto, Yoshikazu
    Usui, Tatsufumi
    Ito, Hiroshi
    Ono, Etsuro
    Ito, Toshihiro
    AVIAN PATHOLOGY, 2015, 44 (04) : 243 - 247
  • [27] Highly Pathogenic Avian Influenza Viruses at the Wild-Domestic Bird Interface in Europe: Future Directions for Research and Surveillance
    Verhagen, Josanne H.
    Fouchier, Ron A. M.
    Lewis, Nicola
    VIRUSES-BASEL, 2021, 13 (02):
  • [28] Different Sensitivity of Japanese Native-Bred Chickens to H5 Subtypes of Highly Pathogenic Avian Influenza Viruses
    Matsuu, Aya
    Tanikawa, Taichiro
    Fujimoto, Yoshikazu
    Yabuki, Mihoko
    Tsunekuni, Ryota
    Sakuma, Saki
    Uchida, Yuko
    Saito, Takehiko
    AVIAN DISEASES, 2021, 65 (03) : 508 - 515
  • [29] Comparative infectivity and transmissibility studies of wild-bird and chicken-origin highly pathogenic avian influenza viruses H5N8 in chickens
    Rohaim, Mohammed A.
    El Naggar, Rania F.
    Madbouly, Yehia
    AbdelSabour, Mohammed A.
    Ahmed, Kawkab A.
    Munir, Muhammad
    COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, 2021, 74
  • [30] Avian influenza surveillance reveals presence of low pathogenic avian influenza viruses in poultry during 2009-2011 in the West Bengal State, India
    Shailesh D Pawar
    Sandeep D Kale
    Amol S Rawankar
    Santosh S Koratkar
    Chandrashekhar G Raut
    Satish A Pande
    Jayati Mullick
    Akhilesh C Mishra
    Virology Journal, 9