Impact of the oxytocin receptor antagonist atosiban administered shortly before embryo transfer on pregnancy rates after ICSI

被引：2
|
作者：
Hebisha, S. A. [1 ]
Adel, Hisham M. [1 ]
机构：
[1] Alexandria Univ, Dept Gynecol, Fac Med, Alexandria, Egypt
来源：
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY | 2018年 / 45卷 / 04期
关键词：
Atosiban; Embryo transfer; ICSI; Clinical pregnancy rate; HUMAN CHORIONIC-GONADOTROPIN; IN-VITRO FERTILIZATION; UTERINE PERISTALSIS; CLINICAL PREGNANCY; CONTROLLED-TRIAL; DOUBLE-BLIND; IMPLANTATION; ENDOMETRIUM; INJECTION; CYCLES;
D O I：
10.12891/ceog3907.2018
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To evaluate the impact of the oxytocin receptor antagonist atosiban on implantation and pregnancy rates after first ICSI trial in good prognosis cases. Design: Randomised controlled trial. Materials and Methods: The study included 182 women, prepared for first trial of ICSI for male or tubal factor infertility, using long agonist protocol, were randomized to receive 7.5 mg atosiban or placebo IV 20 minutes before embryo transfer (ET). Results: Fifty-eight (63.7%) cases had ongoing pregnancy in the study group while 44 (48.4%) cases had ongoing pregnancy in control group and this was statistically significant (p = 0.037). Implantation rates were 45.20%, and 34.69%, respectively, which was also statistically significant (p = 0.045). All of the intermediate cycle parameters were also comparable. Conclusion: Atosiban in the given dose and regimen improved both implantation and on going pregnancy rates in good prognosis cases undergoing first ICSI trial and blastocyst stage embryo transfer.
引用
收藏
页码：513 / 516
页数：4
相关论文
共 50 条
  • [41] Fertilization, pregnancy and embryo implantation rates after ICSI with fresh or frozen-thawed testicular spermatozoa
    De Croo, I
    Van der Elst, J
    Everaert, K
    De Sutter, P
    Dhont, M
    HUMAN REPRODUCTION, 1998, 13 : 133 - 134
  • [42] Impact of Oocyte Morphology on Fertilization, Embryo Quality and Pregnancy after ICSI: Evaluation with Diabetes and PCOS
    Abu-Elnaga, N. A.
    Mehaney, A. B.
    Youssef, H. M. G.
    Mahmoud, S. M.
    Salim, A. S.
    ARAB JOURNAL OF NUCLEAR SCIENCES AND APPLICATIONS, 2019, 52 (04): : 110 - 118
  • [43] A PLACEBO-CONTROLLED, RANDOMIZED, DOUBLE-BLIND, PHASE 3 STUDY ASSESSING ONGOING PREGNANCY RATES AFTER SINGLE ORAL ADMINISTRATION OF A NOVEL OXYTOCIN RECEPTOR ANTAGONIST, NOLASIBAN, PRIOR TO SINGLE EMBRYO TRANSFER.
    Visnova, H.
    Tournaye, H. J.
    Humberstone, A.
    Terrill, P.
    Macgregor, L.
    Loumaye, E.
    FERTILITY AND STERILITY, 2018, 110 (04) : E45 - E45
  • [44] The impact of stress and anxiety during embryo transfer on pregnancy rates: a prospective trial
    Leis, L. Luciana
    Tso, L. O.
    Antunes, N., Jr.
    Soares, J. B.
    Tognotti, E.
    Zulli, K.
    Glina, S.
    Velloso, C. M.
    Rodrigues, A.
    Busso, N. E.
    HUMAN REPRODUCTION, 2014, 29 : 264 - 264
  • [45] Impact of physician performing embryo transfer on pregnancy rates in an assisted reproductive program
    Angelini, Antonio
    Brusco, Gian Francesco
    Barnocchi, Nicoletta
    El-Danasouri, Imam
    Pacchiarotti, Arianna
    Selman, Helmy A.
    JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2006, 23 (7-8) : 329 - 332
  • [46] Impact of Physician Performing Embryo Transfer on Pregnancy Rates in an Assisted Reproductive Program
    Antonio Angelini
    Gian Francesco Brusco
    Nicoletta Barnocchi
    Imam El-Danasouri
    Arianna Pacchiarotti
    Helmy A. Selman
    Journal of Assisted Reproduction and Genetics, 2006, 23 : 329 - 332
  • [47] The impact of severe endometriosis on embryo quality and pregnancy rate after intracytoplasmic sperm injection (ICSI)
    Sudiman, J.
    Tondohusodo, N.
    Suardika, A.
    Adnyana, I. P.
    HUMAN REPRODUCTION, 2016, 31 : 226 - 226
  • [48] Ongoing and cumulative pregnancy rates after cleavage stage embryo transfer: impact of the day of cryopreservation of the supernumerary embryos
    De Croo, I.
    Tilleman, K.
    De Gheselle, S.
    Van de Velde, A.
    Heindryckx, B.
    Vandekerckhove, F.
    Van den Abbeel, E.
    De Sutter, P.
    HUMAN REPRODUCTION, 2016, 31 : 377 - 377
  • [49] Effects of differences in response to ovarian stimulation on pregnancy rates and implantation rates per embryo after IVF and embryo transfer
    Pinas, MS
    Peters, MHEC
    Fauser, BCJM
    HUMAN REPRODUCTION, 1997, 12 : R232 - R232
  • [50] Administration of oxytocin antagonist at the same time as using a Foley catheter with cotton swab before embryo transfer for cervical stenosis
    Chae, Heesuk
    BMC WOMENS HEALTH, 2021, 21 (01)
12345