Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety

被引：82
|
作者：
Ratkovic, Zoran [1 ]
Juranic, Zorica D. [2 ]
Stanojkovic, Tatjana [2 ]
Manojlovic, Dragan [3 ]
Vukicevic, Rastko D. [1 ]
Radulovic, Niko [4 ]
Joksovic, Milan D. [1 ]
机构：
[1] Univ Kragujevac, Fac Sci, Kragujevac 34000, Serbia
[2] Inst Oncol & Radiol Serbia, Belgrade 11000, Serbia
[3] Univ Belgrade, Fac Chem, Belgrade 11000, Serbia
[4] Univ Nis, Dept Chem, Fac Sci & Math, Nish 18000, Serbia
来源：
BIOORGANIC CHEMISTRY | 2010年 / 38卷 / 1-3期
关键词：
Ferrocene; Chalcone analogues; Pyrazole; Cytotoxicity; RAPID COLORIMETRIC ASSAY; CELL-GROWTH; DERIVATIVES; LINES;
D O I：
10.1016/j.bioorg.2009.09.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of new raft-unsaturated conjugated ketones containing ferrocenyl pyrazole unit were synthesized and fully characterized by IR and NMR spectroscopy. Electrochemical characterization of subject compounds was performed by means of cyclic voltametry. The in vitro cytotoxic activity of all the synthesized compounds was studied against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines by the MIT method. Derivative II containing 3-pyridyl moiety exhibited a better cytotoxic activity in the cell growth inhibition of 1(562 cell lines in comparison with cisplatin as a reference compound. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：26 / 32
页数：7
相关论文
共 50 条
  • [31] Synthesis and Preliminary Biological Activity of Some New Pyrazole Derivatives as Acyclonucleoside Analogues
    Radi, Smaail
    Salhi, Souad
    Radi, Amal
    LETTERS IN DRUG DESIGN & DISCOVERY, 2010, 7 (01) : 27 - 30
  • [32] Synthesis, characterization, and anticancer properties of ferrocenyl complexes containing a salicylaldehyde moiety
    Abd-Elzaher, Mokhles M.
    Moustafa, Samia A.
    Labib, Ammar A.
    Ali, Mamdouh M.
    MONATSHEFTE FUR CHEMIE, 2010, 141 (04): : 387 - 393
  • [33] Synthesis, characterization, and anticancer properties of ferrocenyl complexes containing a salicylaldehyde moiety
    Mokhles M. Abd-Elzaher
    Samia A. Moustafa
    Ammar A. Labib
    Mamdouh M. Ali
    Monatshefte für Chemie - Chemical Monthly, 2010, 141 : 387 - 393
  • [34] Synthesis, spectroscopy and biological activity of novel acylhydrazines containing ferrocenyl moiety
    Huang, RQ
    Wang, QM
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2001, 637 : 94 - 98
  • [35] Synthesis and Biological Activity of Novel Statine Derivatives Containing Ferrocenyl Moiety
    Gu, Lijun
    Yang, Bingqin
    Liu, Feilong
    JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2010, 21 (01) : 58 - U39
  • [36] SYNTHESIS OF NEW HETEROCYCLIC-COMPOUNDS CONTAINING A PYRAZOLE MOIETY
    HAMMOUDA, HA
    HUSSAIN, SM
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1985, 24 (06): : 632 - 635
  • [37] Synthesis, characterization and antitumor activity of novel ferrocene derivatives containing pyrazolyl-moiety
    Huang, Xian-Feng
    Wang, Ling-Zhu
    Tang, Long
    Lu, Ying-Xun
    Wang, Fan
    Song, Guo-Qiang
    Ruan, Ban-Feng
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2014, 749 : 157 - 162
  • [38] Synthesis and Antitumor Activity Evaluation of Pyrimidine Analogues Bearing Urea Moiety
    Shao, Kunpeng
    Zhang, Xuyao
    Zhang, Xiaosong
    Xue, Dengqi
    Ma, Liying
    Zhang, Qiurong
    Liu, Hongmin
    CHINESE JOURNAL OF CHEMISTRY, 2014, 32 (05) : 443 - 447
  • [39] Synthesis, characterization, POM analysis and antifungal activity of novel heterocyclic chalcone derivatives containing acylated pyrazole
    Helmi Mohammed Al-Maqtari
    Joazaizulfazli Jamalis
    Taibi Ben Hadda
    Murugesan Sankaranarayanan
    Subhash Chander
    Noor Aisyah Ahmad
    Hasnah Mohd Sirat
    Ismail I. Althagafi
    Yahia Naseer Mabkhot
    Research on Chemical Intermediates, 2017, 43 : 1893 - 1907
  • [40] Synthesis, characterization, POM analysis and antifungal activity of novel heterocyclic chalcone derivatives containing acylated pyrazole
    Al-Maqtari, Helmi Mohammed
    Jamalis, Joazaizulfazli
    Ben Hadda, Taibi
    Sankaranarayanan, Murugesan
    Chander, Subhash
    Ahmad, Noor Aisyah
    Sirat, Hasnah Mohd
    Althagafi, Ismail I.
    Mabkhot, Yahia Naseer
    RESEARCH ON CHEMICAL INTERMEDIATES, 2017, 43 (03) : 1893 - 1907
12345