Pregnancy outcome in Factor XI deficiency: incidence of miscarriage, antenatal and postnatal haemorrhage in 33 women with Factor XI deficiency

被引:36
|
作者
Myers, B.
Pavord, S.
Kean, L.
Hill, M.
Dolan, G.
机构
[1] Queens Med Ctr, Dept Haematol, Nottingham NG7 2UH, England
[2] Leicester Royal Infirm, Dept Haematol, Leicester, Leics, England
[3] City Hosp Nottingham, Dept Fetal & Maternal Med, Nottingham, England
关键词
Factor XI deficiency; pregnancy complications;
D O I
10.1111/j.1471-0528.2007.01296.x
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Pregnancy complications in women with Factor XI deficiency were assessed in this retrospective analysis. All nonnulliparous women registered with Factor XI deficiency in the East Midlands region were included. Each woman was classified into 'bleeder' or 'nonbleeder'. Rates of antenatal and postnatal bleeding and miscarriage rate were recorded. A total of 33 women had 105 pregnancies. Pregnancy and delivery was uneventful in 70% of the cases. Postpartum haemorrhage (PPH) appears increased in women with a 'bleeding' phenotype with a highly significant difference between 'bleeders' and 'nonbleeders' (relative risk [RR] 7.2; CI 1.99-25.9). Miscarriage rate appeared unchanged. We conclude that PPH is increased in a subgroup with a bleeding phenotype. Larger studies are needed to define the underlying factors.
引用
收藏
页码:643 / 646
页数:4
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