Pregnancy complications in women with Factor XI deficiency were assessed in this retrospective analysis. All nonnulliparous women registered with Factor XI deficiency in the East Midlands region were included. Each woman was classified into 'bleeder' or 'nonbleeder'. Rates of antenatal and postnatal bleeding and miscarriage rate were recorded. A total of 33 women had 105 pregnancies. Pregnancy and delivery was uneventful in 70% of the cases. Postpartum haemorrhage (PPH) appears increased in women with a 'bleeding' phenotype with a highly significant difference between 'bleeders' and 'nonbleeders' (relative risk [RR] 7.2; CI 1.99-25.9). Miscarriage rate appeared unchanged. We conclude that PPH is increased in a subgroup with a bleeding phenotype. Larger studies are needed to define the underlying factors.
机构:
Harvard Univ, Sch Med, Dept Anesthesiol, Div Obstet Anesthesiol, Boston, MA USAHarvard Univ, Sch Med, Dept Anesthesiol, Div Obstet Anesthesiol, Boston, MA USA
Singh, Amarjeet
Harnett, Miriam J.
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机构:
Harvard Univ, Sch Med, Dept Anesthesiol, Div Obstet Anesthesiol, Boston, MA USAHarvard Univ, Sch Med, Dept Anesthesiol, Div Obstet Anesthesiol, Boston, MA USA
Harnett, Miriam J.
Connors, Jean M.
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机构:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Hematol,Dept Med, Boston, MA USAHarvard Univ, Sch Med, Dept Anesthesiol, Div Obstet Anesthesiol, Boston, MA USA
Connors, Jean M.
Camann, William R.
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机构:
Harvard Univ, Sch Med, Dept Anesthesiol, Div Obstet Anesthesiol, Boston, MA USAHarvard Univ, Sch Med, Dept Anesthesiol, Div Obstet Anesthesiol, Boston, MA USA
Camann, William R.
ANESTHESIA AND ANALGESIA,
2009,
108
(06):
: 1882
-
1885
机构:
Univ Milan, Dipartimento Biotecnol Med & Med Traslaz, Milan, ItalyUniv Milan, Dipartimento Biotecnol Med & Med Traslaz, Milan, Italy
Duga, Stefano
Salomon, Ophira
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机构:
Tel Aviv Univ, Tel Hashomer & Sackler Fac Med, Amalia Biron Res Inst Thrombosis & Hemostasis, Chaim Sheba Med Ctr, IL-69978 Tel Aviv, IsraelUniv Milan, Dipartimento Biotecnol Med & Med Traslaz, Milan, Italy
Salomon, Ophira
SEMINARS IN THROMBOSIS AND HEMOSTASIS,
2013,
39
(06):
: 621
-
631