An efficient one-pot synthesis and biological evaluation of novel (E)-2-aroyl-4-arylidene-5-oxotetrahydrofuran derivatives

被引：7
|
作者：
Wang, Hong-Mei [1 ,2 ,3 ]
Zhu, Xiu-Lian [1 ,2 ,3 ]
Chen, Qin-Hua [2 ]
Ding, Ming-Wu [4 ]
Zeng, Xiao-Hua [3 ]
机构：
[1] Hubei Univ Med, Dongfeng Hosp, Expt Ctr Med, Shiyan, Peoples R China
[2] Shenzhen Baoan Authent TCM Therapy Hosp, Shenzhen 518101, Guangdong, Peoples R China
[3] Hubei Univ Med, Sch Pharmaceut Sci, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Peoples R China
[4] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China
来源：
JOURNAL OF CHEMICAL RESEARCH | 2021年 / 45卷 / 5-6期
基金：
湖北省教育厅重点项目; 中国国家自然科学基金;
关键词：
cancer; (E)-2-aroyl-4-arylidene-5-oxotetrahydrofurans; one-pot; proliferation; synthesis; ACID;
D O I：
10.1177/1747519820958626
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient one-pot base-mediated approach to (E)-2-aroyl-4-arylidene-5-oxotetrahydro-furans is developed. Nine (E)-2-aroyl-4-arylidene-5-oxotetrahydrofurans are synthesized in good yields via tandem Passerini and cyclization reactions, starting from Baylis-Hillman acids, aryl glyoxals, and isocyanides at room temperature in the presence of Cs2CO3. In addition, the MTT assay is used to evaluate their cytotoxicities toward the cervical cancer cell lines C-33A, CaSki, and SiHa and the hepatocarcinoma cell line HepG2. The results show that some of the compounds inhibit the proliferation of cancer cells significantly.
引用
收藏
页码：395 / 399
页数：5
相关论文
共 50 条
  • [21] One-pot multicomponent designing of novel 2-imino-4-arylidene-1,3-thiazolidin-4-one
    Amer, Amer A.
    Abdelhamid, Antar A.
    Elnakeeb, Amany Sh.
    Salah, Hanan A.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2023, 60 (03) : 489 - 496
  • [22] One-pot synthesis and biological evaluation of aspergillamides and analogues
    Beck, B
    Hess, S
    Dömling, A
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (15) : 1701 - 1705
  • [23] One-pot synthesis of 2, 4, 5-trinitroimidazole
    School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing
    210094, China
    Hanneng Cailiao, 5 (722-724):
  • [24] Regioselective synthesis and biological evaluation of novel dispiropyrrolidine derivatives via one-pot four-component reaction
    Hegde, Subramanya Gopal
    Koodlur, Lokesh
    Narayanarao, Manjunatha
    SYNTHETIC COMMUNICATIONS, 2019, 49 (24) : 3453 - 3464
  • [25] Synthesis and Biological Evaluation of the Forssman Antigen Pentasaccharide and Derivatives by a One-Pot Glycosylation Procedure
    Tanaka, Hiroshi
    Takeuchi, Ryota
    Jimbo, Mitsuru
    Kuniya, Nami
    Takahashi, Takashi
    CHEMISTRY-A EUROPEAN JOURNAL, 2013, 19 (09) : 3177 - 3187
  • [26] An efficient one-pot synthesis of novel pyrazolophthalazinyl spirooxindoles
    Shanthi, Gnanamani
    Perumal, Paramasivan T.
    JOURNAL OF CHEMICAL SCIENCES, 2010, 122 (03) : 415 - 421
  • [27] An efficient one-pot synthesis of novel pyrazolophthalazinyl spirooxindoles
    Gnanamani Shanthi
    Paramasivan T. Perumal
    Journal of Chemical Sciences, 2010, 122 : 415 - 421
  • [28] Efficient one-pot synthesis of ethyl 2-substitued-4-methylthiazole-5-carboxylates
    Meng, Ge
    Wang, Mei
    Zheng, Aqun
    Dou, Jianwei
    Guo, Zengjun
    GREEN CHEMISTRY LETTERS AND REVIEWS, 2014, 7 (01) : 46 - 49
  • [29] An efficient One-Pot synthesis of NaOCl mediated pyrazolopyrimidine derivatives
    Chandu, Sampoorna
    Varkolu, Mohan
    RESULTS IN CHEMISTRY, 2024, 11
  • [30] An efficient one-pot synthesis of novel 4-aryl-1-methyloxindoles
    van den Hoogenband, Adri
    Lange, Jos H. M.
    Iwema-Bakker, Wouter I.
    den Hartog, Jack A. J.
    van Schaik, Jord
    Feenstra, Rolf W.
    Terpstra, Jan Willem
    TETRAHEDRON LETTERS, 2006, 47 (26) : 4361 - 4364
12345