An efficient one-pot synthesis and biological evaluation of novel (E)-2-aroyl-4-arylidene-5-oxotetrahydrofuran derivatives

被引：7

作者：

Wang, Hong-Mei ^{[1
,2
,3
]}

Zhu, Xiu-Lian ^{[1
,2
,3
]}

Chen, Qin-Hua ^{[2
]}

Ding, Ming-Wu ^{[4
]}

Zeng, Xiao-Hua ^{[3
]}

机构：

[1] Hubei Univ Med, Dongfeng Hosp, Expt Ctr Med, Shiyan, Peoples R China

[2] Shenzhen Baoan Authent TCM Therapy Hosp, Shenzhen 518101, Guangdong, Peoples R China

[3] Hubei Univ Med, Sch Pharmaceut Sci, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Peoples R China

[4] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH | 2021年 / 45卷 / 5-6期

基金：

湖北省教育厅重点项目; 中国国家自然科学基金;

关键词：

cancer; (E)-2-aroyl-4-arylidene-5-oxotetrahydrofurans; one-pot; proliferation; synthesis; ACID;

D O I：

10.1177/1747519820958626

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient one-pot base-mediated approach to (E)-2-aroyl-4-arylidene-5-oxotetrahydro-furans is developed. Nine (E)-2-aroyl-4-arylidene-5-oxotetrahydrofurans are synthesized in good yields via tandem Passerini and cyclization reactions, starting from Baylis-Hillman acids, aryl glyoxals, and isocyanides at room temperature in the presence of Cs2CO3. In addition, the MTT assay is used to evaluate their cytotoxicities toward the cervical cancer cell lines C-33A, CaSki, and SiHa and the hepatocarcinoma cell line HepG2. The results show that some of the compounds inhibit the proliferation of cancer cells significantly.

引用

页码：395 / 399

页数：5

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