Generation and characterization of an induced pluripotent stem cell line (FJMUNi001-A) from a patient with Duchenne muscular dystrophy carrying c.4518+512 T > A variant in the DMD gene

被引：0

作者：

Jin, Ming ^{[1
]}

Wang, Danni ^{[2
]}

Li, Guoling ^{[3
]}

Lin, Jiajia ^{[1
]}

Lin, Xiang ^{[1
]}

Wang, Ning ^{[1
]}

机构：

[1] Fujian Med Univ, Affiliated Hosp 1, Fujian Inst Neurol, Dept Neurol, Fuzhou, Peoples R China

[2] Xiamen Univ, Affiliated Hosp 1, Sch Med, Dept Neurol, Xiamen, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, CAS Ctr Excellence Brain Sci & Intelligence Techno, Shanghai, Peoples R China

来源：

STEM CELL RESEARCH | 2022年 / 60卷

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/j.scr.2022.102718

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Duchenne muscular dystrophy (DMD) is an X-linked recessive degenerative disease characterized by progressive weakness of limbs. In this study, we generated an induced pluripotent stem cell line from a DMD patient's dermal fibroblasts with non-integrating Sendai virus. The patient carried a rare c.4518 + 512 T > A variant in the DMD gene. This iPSC line displayed normal iPSC morphology, karyotypes and pluripotency expression markers, and also can be differentiated into the three germ layers.

引用

页数：4

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Generation and characterization of an induced pluripotent stem cell line (FJMUNi001-A) from a patient with Duchenne muscular dystrophy carrying c.4518+512 T &gt; A variant in the DMD gene

Generation and characterization of an induced pluripotent stem cell line (FJMUNi001-A) from a patient with Duchenne muscular dystrophy carrying c.4518+512 T > A variant in the DMD gene