Comparison of Choriocapillaris Flow Measurements between Two Optical Coherence Tomography Angiography Devices

Purpose: To evaluate choriocapillaris (CC) perfusion in healthy subjects using 2 different optical coherence tomography angiography (OCT-A) devices. Procedures: Macular OCT-A imaging (36 eyes of 36 subjects) was performed using Optovue AngioVue and Zeiss AngioPlex devices. CC decorrelation signal index was assessed, and CC data were analyzed regarding intra-device variability, inter-device correlation, age, signal strength, and fields of view. Results: The intra-device variability of CC measurements in the 3 x 3 mm(2) field was 5.3 and 2.6% (Angiovue and Angioplex, coefficients of variation; 6 x 6 mm(2) : 8.0 and 2.8%, respectively). Mean CC decorrelation signal index in 3 x 3 mm(2) was 104.3 +/- 6.7 (Angiovue) and 81.3 +/- 9.2 (Angioplex) (6 x 6 mm(2) : 95.6 +/- 8.1, 81.1 +/- 6.5) with high correlation between both devices (3 x 3 mm(2) : p = 0.0053; 6 x 6 mm(2) : p = 0.0139). CC decorrelation signal index in 3 x 3 mm(2) was significantly higher in subjects aged <= 58 years compared to subjects aged >= 59 years (Angiovue: 107.3 +/- 3.6, 101.3 +/- 7.7, p = 0.0156; Angioplex: 84.6 +/- 7.6, 78.0 +/- 9.5, p = 0.0371). Signal strength was 64.6 +/- 8.9 (Angiovue) and 9.5 +/- 0.8 (Angioplex). Conclusion: Both devices showed low intra-device variability and a high inter-device correlation. CC decorrelation signal index was negatively correlated with advancing age. (C) 2017 S. Karger AG, Basel