Integrated process synthesis of large-scale chemical processes

The paper presents the combined conceptual-rigorous approach to the problem of energy integrated process synthesis of large-scale chemical processes. The process design is composed of three main steps, i.e. simulation step, conceptual design step (extended Pinch design method, determination of promising modifications. their assessment, selection of the most promising modification) and rigorous design step (structural and parameter optimization). The proposed method was tested using a case study of a simplified ammonia production where the marginal cost decrease of 1.2%, has been achieved compared to the base process design.