Generation of three spinocerebellar ataxia type-12 patients derived induced pluripotent stem cell lines (IGIBi002-A, IGIBi003-A and IGIBi004-A)

被引：7
|
作者：
Kumar, Deepak [1 ,2 ]
Hussain, Ashaq [3 ]
Srivastava, Achal K. [2 ]
Mukerji, Mitali [1 ]
Mukherjee, Odity [4 ]
Faruq, Mohammed [1 ]
机构：
[1] IGIB, CSIR, Genom & Mol Med, Mall Rd, Delhi 110007, India
[2] All India Inst Med Sci, Neurosci Ctr, Dept Neurol, New Delhi 110029, India
[3] Hamdard Univ, Jamia Hamdard, New Delhi, India
[4] Inst Stem Cell Biol & Regenerat Med InStem, Bangalore, Karnataka, India
来源：
STEM CELL RESEARCH | 2018年 / 31卷
关键词：
D O I：
10.1016/j.scr.2018.08.008
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Spinocerebellar ataxia type-12 (SCA12) is a neurological disorder caused due to triplet (CAG) repeat expansion in 5' UTR of PPP2R2B. It is one of the most prominent SCA-subtype in Indian population and fill date no patient specific models have been described. Human-induced-pluripotent-stem cell (HiPSC) based disease modelling has become the next generation tool for studying various human pathologies. In the present study we established three SCA12 patient specific iPSC lines. All the generated lines have shown pluripotency markers, normal karyotype, in-vitro three germ layers differentiation potential, vector clearance, SCA12 mutation, parental genomic identity and contamination free culture.
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收藏
页码：216 / 221
页数：6
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