Targeting tumours with genetically enhanced T lymphocytes

被引：412
|
作者：
Sadelain, M
Rivière, I
Brentjens, R
机构：
[1] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA
[2] Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10021 USA
来源：
NATURE REVIEWS CANCER | 2003年 / 3卷 / 01期
关键词：
D O I：
10.1038/nrc971
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The genetic modification of T lymphocytes is an important approach to investigating normal T-cell biology and to increasing antitumour immunity. A number of genetic strategies aim to increase the recognition of tumour antigens, enhance antitumour activities and prevent T-cell malfunction. T cells can also be engineered to increase safety, as well as to express markers that can be tracked by non-invasive imaging technologies. Genetically modified T cells are therefore proving to be of great value for basic immunology and experimental immunotherapy.
引用
收藏
页码：35 / 45
页数：11
相关论文
共 50 条
  • [31] Tumour-infiltrating cytotoxic T lymphocytes in somatotroph pituitary neuroendocrine tumours
    Iacovazzo, Donato
    Chiloiro, Sabrina
    Carlsen, Eivind
    Bianchi, Antonio
    Giampietro, Antonella
    Tartaglione, Tommaso
    Bima, Chiara
    Bracaccia, Maria Elena
    Lugli, Francesca
    Lauretti, Liverana
    Anile, Carmelo
    Gessi, Marco
    Colosimo, Cesare
    Rindi, Guido
    Pontecorvi, Alfredo
    Korbonits, Marta
    De Marinis, Laura
    ENDOCRINE, 2020, 67 (03) : 651 - 658
  • [32] Tumour-infiltrating cytotoxic T lymphocytes in somatotroph pituitary neuroendocrine tumours
    Donato Iacovazzo
    Sabrina Chiloiro
    Eivind Carlsen
    Antonio Bianchi
    Antonella Giampietro
    Tommaso Tartaglione
    Chiara Bima
    Maria Elena Bracaccia
    Francesca Lugli
    Liverana Lauretti
    Carmelo Anile
    Marco Gessi
    Cesare Colosimo
    Guido Rindi
    Alfredo Pontecorvi
    Márta Korbonits
    Laura De Marinis
    Endocrine, 2020, 67 : 651 - 658
  • [33] Targeting tumours [radiotherapy]
    Greenaway, Beth
    Engineering and Technology, 2008, 3 (17): : 44 - 47
  • [34] Targeting tumours with HSV
    Fricker, J
    DRUG DISCOVERY TODAY, 2000, 5 (01) : 5 - 6
  • [35] Genetically determined gonadal tumours in children
    Audí, L
    Torán, N
    Piró, C
    Gussinyé, M
    Carrascosa, A
    JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 2005, 18 : 1215 - 1225
  • [36] CD34-based enrichment of genetically engineered human T cells for clinical use results in dramatically enhanced tumor targeting
    Norell, Hakan
    Zhang, Yi
    McCracken, James
    da Palma, Telma Martins
    Lesher, Aaron
    Liu, Yueying
    Roszkowski, Jeffrey J.
    Temple, Anquanette
    Callender, Glenda G.
    Clay, Timothy
    Orentas, Rimas
    Guevara-Patino, Jose
    Nishimura, Michael I.
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2010, 59 (06) : 851 - 862
  • [37] CD34-based enrichment of genetically engineered human T cells for clinical use results in dramatically enhanced tumor targeting
    Håkan Norell
    Yi Zhang
    James McCracken
    Telma Martins da Palma
    Aaron Lesher
    Yueying Liu
    Jeffrey J. Roszkowski
    Anquanette Temple
    Glenda G. Callender
    Timothy Clay
    Rimas Orentas
    José Guevara-Patiño
    Michael I. Nishimura
    Cancer Immunology, Immunotherapy, 2010, 59 : 851 - 862
  • [38] A Platform for the Scalable Derivation of Genetically-Enhanced T and NK Lymphocytes from Naive Human Induced Pluripotent Stem Cells for Cancer Immunotherapy
    Clarke, Raedun
    Kim, William
    Groff, Brian
    Abujarour, Ramzey
    Robinson, Megan
    Huang, Xiaosong
    Sahaf, Newsha
    Raynel, Sarah
    Rezner, Betsy
    Robbins, David
    Guerrettaz, Lisa
    Shoemaker, Daniel
    Valamehr, Bahram
    BLOOD, 2015, 126 (23)
  • [39] ENHANCED SUSCEPTIBILITY TO HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION IN CD4(+) T-LYMPHOCYTES GENETICALLY DEFICIENT IN CD43
    SRINIVAS, RV
    SU, T
    TRIMBLE, LA
    LIEBERMAN, J
    ARDMAN, B
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 1995, 11 (09) : 1015 - 1021
  • [40] Targeting the tumour vasculature with CAR T-cells for treatment of solid tumours
    Sanchez-Nieto, J. M.
    Guijaro-Leach, J. J.
    Camicia, R.
    Keogh, A.
    Ricardo, C. P.
    Labbe, R.
    Petrovic, R.
    Gargiulo, L.
    Robinson, J.
    Zhuang, X.
    Jinks, E.
    Whitworth, K.
    Bystrom, J.
    Sharif, M.
    Nagy, Z.
    Tordo, J.
    Mccoy, R.
    Kallmeier, R.
    Sharpe, M.
    Bicknell, R.
    Lee, S.
    Munye, M. M.
    HUMAN GENE THERAPY, 2019, 30 (08) : A14 - A15
12345